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Claims for Patent: 4,338,325

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Claims for Patent: 4,338,325

Title: PGI.sub.2 Pharmacologically acceptable salts
Abstract:The present invention relates to PGI.sub.2 pharmacologically acceptable salts, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
Inventor(s): Johnson; Roy A. (Kalamazoo, MI), Lincoln; Frank H. (Portage, MI), Pike; John E. (Kalamazoo, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:06/200,690
Patent Claims: 1. A composition of matter consisting essentially of a pharmacologically acceptable salt of a compound of formula I ##STR3##

2. A composition according to claim 1 wherein said pharmacologically acceptable salt is the benzyltrimethylammonium salt.

3. A composition according to claim 1 wherein said pharmacologically acceptable salt is the tetramethylammonium salt.

4. A composition according to claim 1 wherein said pharmacologically acceptable salt is the sodium salt.

5. A composition according to claim 4 in a free flowing powder form.

6. A parenteral pharmaceutical composition for inhibition of platelet aggregation characterized in being prepared from

(1) a free flowing powder form of the sodium salt of PGI.sub.2, a compound of formula I ##STR4## and (2) a conventional pharmaceutical diluent for parenteral formulations, such that the sodium salt of PGI.sub.2 is present in said composition at a concentration sufficient to inhibit platelet aggregation upon administration of a said composition in a predetermined volume or at a predetermined rate.
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