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Claims for Patent: 4,338,317

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Claims for Patent: 4,338,317

Title: Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
Abstract:Phenoxyethyl substituted-1,2,4,-triazolones having antidepressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one are disclosed.
Inventor(s): Temple, Jr.; Davis L. (Evansville, IN), Lobeck, Jr.; Walter G. (Evansville, IN)
Assignee: Mead Johnson & Company (Evansville, IN)
Application Number:06/244,464
Patent Claims: 1. A compound of Formula I ##STR17## wherein R is halogen or a pharmaceutically acceptable acid addition salt thereof.

2. The compound of claim 1 which is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one.

3. The compound of claim 1 which is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one hydrochloride.

4. The method for treating a mammal afflicted with depression comprising administering to said mammal a therapeutically effective antidepressant amount of a compound of claim 1 or a pharmaceutically acceptable acid addition salt thereof.

5. The method of claim 4 wherein the compound is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one.

6. The method of claim 4 wherein the compound is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one hydrochloride.

7. The pharmaceutical composition comprising an antidepressant amount of a compound of claim 1 or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier.

8. The pharmaceutical composition of claim 7 wherein the compound is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one.

9. The pharmaceutical composition of claim 7 wherein the compound is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one hydrochloride.
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