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Claims for Patent: 4,329,356

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Claims for Patent: 4,329,356

Title: Treatment of hypertension with fluoxetine and l-5-hydroxytryptophane
Abstract:Fluoxetine alone or a combination of fluoxetine and l-5-hydroxytryptophan, preferably also with a peripheral decarboxylase inhibitor, is administered to hypertensive mammals to lower blood pressure.
Inventor(s): Holland; Donald R. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:06/202,847
Patent Claims: 1. A method for lowering blood pressure in a hypertensive mammal in need of treatment which comprises the co-administration of hypotensively effective amounts of fluoxetine and l-5-hydroxytryptophane or pharmaceutically acceptable salts thereof, the amount of said combination administered being significantly effective to reduce the blood pressure of said hypertensive mammal, compared to each alone.

2. A process according to claim 1 in which the drugs are administered orally.

3. A process according to claim 2 in which fluoxetine is administered as a hydrochloride salt.

4. A process according to claim 3 in which the fluoxetine hydrochloride daily dosage level is 0.5-2 mg./kg. of mammalian body weight.

5. A process according to claim 2 in which the l-5-tryptophane daily dose level is from 3-40 mg/kg of mammalian body weight.

6. A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the co-administration of hypotensively-effective amounts of fluoxetine, and l-5-tryptophan or pharmaceutically acceptable salts thereof, the amount of said combination, compared to each alone, being significantly effective to reduce the blood pressure of said hypertensive mammals plus a peripheral decarboxylase inhibitor in an amount sufficient to prevent side effects attributable to serotonin.

7. A process according to claim 6 in which the drugs are administered orally.

8. A process according to claim 7 in which fluoxetine is administered as a hydrochloride salt.

9. A process according to claim 6 in which the peripheral decarboxylase inhibitor is carbidopa.

10. A process according to claim 8 in which the fluoxetine hydrochloride daily dose level is from 0.5-2.0 mg/kg of mammalian body weight.

11. A process according to claim 7 in which the l-5-tryptophan daily dose level is from 2-40 mg/kg of mammalian body weight.

12. A process according to claim 9 in which the daily carbidopa dose level if from 1-6 mg/kg of mammalian body weight.

13. A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the administration to such a mammal of an antihypertensive amount of fluoxetine or a pharmaceutically-acceptable salt thereof.

14. A process according to claim 13 in which fluoxetine or a pharmaceutically-acceptable salt thereof is administered by the oral route.

15. A process according to claim 13 in which fluoxetine hydrochloride is administered.

16. A process according to claim 13 in which the fluoxetine daily dose level is from 0.5-2.0 mg/kg of mammalian body weight.
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