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Generated: October 24, 2017

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Claims for Patent: 4,324,779

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Claims for Patent: 4,324,779

Title: Method for treating hypertonia with N-(2-furfuryl)-4-chloro-5-sulfamoyl-anthranilic acid and preparations thereof
Abstract:A method for treating hypertonia with a preparation of N-(2-furfuryl)-4-chloro-5-sulfamoyl-anthranilic acid having a slightly retarded release, wherein the release of the active substance in vitro, measured in the flow through-cell to Dibbern, is not more than 5% after 1 hour in a buffer solution of pH 1.5 and about 10 to at most 25% of the active substance content after a two-hour treatment in a buffer solution of pH 5.5.
Inventor(s): Dahlhausen; Gebhard (Kronberg, DE), Dibbern; Hans-Werner (Kelkheim, DE), Fulberth (Kelkheim, DE), Ross; Gerhard (Kriftel, DE)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:06/077,181
Patent Claims: 1. A furosemide-containing pellet for the oral administration of furosemide, said pellet consisting essentially of a core of furosemide having thereover a sustained-release coating which starts to dissolve in a weakly acid medium, which coating, when its release characteristics are measured in vitro in a flow-through-cell according to Dibbern,

(a) releases not more than 5 percent of said furosemide into a buffer solution having a pH of 1.5 during the first hour of measurement in said cell;

(b) releases about 10 to at most 25 percent of said furosemide into a buffer solution having a pH of 5.5 during the second hour of measurement in said cell; and

(c) releases the remainder of said furosemide substantially completely into a buffer solution having a pH of 7.5 during the third and fourth hours of measurement in said cell.
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