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Last Updated: December 11, 2025

Claims for Patent: 4,316,897

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Summary for Patent: 4,316,897

Title:	Method of lowering serum prolactin
Abstract:	Benzodiazepine derivatives which have tranquillizing activity, especially 1,4-benzodiazepine derivatives, can lower the serum prolactin concentration. They can reduce, dosage-dependently, the increase in the serum prolactin concentration induced by the administration of neuroleptics, which can lead to undesirable side-effects, when about 0.01 to 100 parts by weight of benzodiazepine derivatives are administered per part by weight of neuroleptic, it being immaterial whether the benzodiazepine derivative is administered before or after the neuroleptic or simultaneously therewith. The simultaneous administration of the active substances can be carried out as an ad hoc combination or in the form of a pharmaceutical combination.
Inventor(s):	Wolfgang Lotz
Assignee:	F Hoffmann La Roche AG, Hoffmann La Roche Inc
Application Number:	US06/185,812
Patent Claims:

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