Proactively manage your pharmacy inventory
Anticipate generic drug launch
Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Find generic entry opportunities
Manage your formulary budget
Drug patents …
… from Kazakhstan to Kalamazoo
Flat-rate pricing for predictable budgeting
Short-term plans for project- or client-based billing
Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Lung surfactant compositions|
|Abstract:||A synthetic protein-free lung surfactant composition is utilized to temporarily substitute for natural lung surfactant in the mammalian lung where such natural lung surfactant is absent or in low concentration. The synthetic surfactant composition consists essentially of a major amount of 1,2-dipalmitoyl-sn-3-glycerophosphoryl choline (DPPC), and a minor amount of a fatty alcohol, preferably a fatty alcohol having from 14 to 18 carbon atoms, and especially n-hexdecan-1-ol. The synthetic surfactant composition is administered directly into the lungs of a distressed subject to create a film on the alveolar interfacial surfaces and reduce surface tension. Expansion of the alveolar spaces is thereby facilitated.|
|Inventor(s):||Clements; John A. (Tiburon, CA)|
|Assignee:||Regents of the University of California (Berkeley, CA)|
1. A mammalian lung surfactant composition consisting essentially of dipalmitoyl phosphatidylcholine in admixture with a fatty alcohol.
2. The composition of claim 1 wherein the fatty alcohol has from about 14 to 18 carbon atoms.
3. The composition of claim 2 wherein the fatty alcohol is hexadecanol.
4. The composition of claim 2 wherein the fatty alcohol is oleic alcohol.
5. The composition of claim 1 wherein the dipalmitoyl phosphotidyl choline constitutes a major percentage by weight of the composition and wherein the fatty alcohol constitutes a minor percentage.
6. The composition of claim 5 wherein the fatty alcohol is present in the range of about 6 to 18% by weight and the dipalmitoyl phosphatidyl choline is present in the range of about 82 to 94% by weight.
7. A composition for administration into mammalian alveolar spaces comprising a suspension of dipalmitoyl phosphatidyl choline and hexadecanol in saline solution.
8. A method for treating respiratory distress syndrome in mammals wherein natural lung surfactant normally produced by the mammal is absent or deficient, comprising introducing into the alveolar spaces a quantity of a composition consisting essentially of a major amount of 1,2 dipalmitoyl-sn-3-glycerophosphoryl choline in admixture with a minor amount of a fatty alcohol.
9. The method of claim 8 wherein the fatty alcohol is n-hexadecan-1-ol.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.