|Abstract:||Novel 5,5-diphenylhydantoins useful as anticonvulsants, antiepileptics and antiarrhythmics have the structural formula: ##STR1## wherein each R is hydrogen or --CH(R.sub.1)--X--P(O)(OH).sub.2, R.sub.1 is hydrogen or C.sub.1 -C.sub.7 straight or branched chain alkyl, and X is O or S, with the proviso that both R's cannot simultaneously be hydrogen.|
|Inventor(s):||Stella; Valentino J. (Lawrence, KS), Sloan; Kenneth B. (Eudora, KS)|
|Assignee:||INTERx Research Corporation (Lawrence, KS)|
1. A 5,5-diphenylhydantoin compound having the structural formula: ##STR12## wherein each R is independently selected from the group consisting of hydrogen and
--CH(R.sub.1)--O--P(O)(OH).sub.2, wherein R.sub.1 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.7 straight or branched chain alkyl; with the proviso that the R's cannot simultaneously be hydrogen; or the pharmaceutically
acceptable acid addition or basic salts, C.sub.1 -C.sub.4 alkylhalide quaternary salts or N-oxide thereof.
2. The compound as defined by claim 1, wherein either R is hydrogen, with the other being --CH(R.sub.1)--O--P(O)(OH).sub.2.
3. The compound as defined by claim 1, same being 3-phosphoryloxymethyl-5,5-diphenylhydantoin.
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