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|Title:||Control of pyrophosphate microorganisms with organophosphonates|
|Abstract:||A method of selectively controlling pyrophosphate-utilizing microorganisms comprises contacting said microorganisms with an organism controlling amount of certain organophosphonate compounds. Accordingly, a method of treating amoebiasis in a human or lower animal comprises administering to a human or lower animal in need of such treatment a safe and effective amount of such organophosphonate compound. Similarly, a method of selectively controlling Propionibacteria species in the manufacture of cheese comprises incorporating an organism controlling amount of an organophosphonate compound in the raw materials for said cheese.|
|Inventor(s):||Triebwasser; Keith C. (Cincinnati, OH)|
|Assignee:||The Proctor & Gamble Company (Cincinnati, OH)|
1. A method for treating amoebiasis comprising administering to a human or lower animal in need of such treatment from about 0.1 to about 5 milligrams/kilogram body
weight/day of a geminal diphosphonate compound having the formula ##STR4## wherein n is an integer from 1 to about 10, R.sub.1 is selected from the group consisting of hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2
to about 20 carbon atoms, phenyl, napthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, --CH(PO.sub.3 H.sub.2)(OH) and --CH.sub.2 CH(PO.sub.3
H.sub.2).sub.2, and R.sup.2 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, amino, benzyl, halogen, hydroxyl, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, and --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2, or a
pharmaceutically-acceptable salts and mixtures thereof.
2. A method according to claim 1 wherein the geminal diphosphonate compound is a member selected from the group consisting of ethane-1-hydroxy-1,1-diphosphonic acid, dichloromethane diphosphonic acid, methane hydroxy diphosphonic acid, nonane 1,1-diphosphonic acid, aminomethane diphosphonic acid, ethane-1-amino-1,1-diphosphonic acid, methane diphosphonic acid, nonane-1-hydroxy-1,1-diphosphonic acid, propane-3-amino-1,1-diphosphonic acid, the pharmaceutically acceptable salts of the above compounds, and mixtures thereof.
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