Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Control of pyrophosphate microorganisms with organophosphonates|
|Abstract:||A method of selectively controlling pyrophosphate-utilizing microorganisms comprises contacting said microorganisms with an organism controlling amount of certain organophosphonate compounds. Accordingly, a method of treating amoebiasis in a human or lower animal comprises administering to a human or lower animal in need of such treatment a safe and effective amount of such organophosphonate compound. Similarly, a method of selectively controlling Propionibacteria species in the manufacture of cheese comprises incorporating an organism controlling amount of an organophosphonate compound in the raw materials for said cheese.|
|Inventor(s):||Triebwasser; Keith C. (Cincinnati, OH)|
|Assignee:||The Proctor & Gamble Company (Cincinnati, OH)|
1. A method for treating amoebiasis comprising administering to a human or lower animal in need of such treatment from about 0.1 to about 5 milligrams/kilogram body
weight/day of a geminal diphosphonate compound having the formula ##STR4## wherein n is an integer from 1 to about 10, R.sub.1 is selected from the group consisting of hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2
to about 20 carbon atoms, phenyl, napthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, --CH(PO.sub.3 H.sub.2)(OH) and --CH.sub.2 CH(PO.sub.3
H.sub.2).sub.2, and R.sup.2 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, amino, benzyl, halogen, hydroxyl, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, and --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2, or a
pharmaceutically-acceptable salts and mixtures thereof.
2. A method according to claim 1 wherein the geminal diphosphonate compound is a member selected from the group consisting of ethane-1-hydroxy-1,1-diphosphonic acid, dichloromethane diphosphonic acid, methane hydroxy diphosphonic acid, nonane 1,1-diphosphonic acid, aminomethane diphosphonic acid, ethane-1-amino-1,1-diphosphonic acid, methane diphosphonic acid, nonane-1-hydroxy-1,1-diphosphonic acid, propane-3-amino-1,1-diphosphonic acid, the pharmaceutically acceptable salts of the above compounds, and mixtures thereof.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.