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Claims for Patent: 4,252,721

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Claims for Patent: 4,252,721

Title: Cycloalkyltriazoles and process for obtaining same
Abstract:Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals; aliphatic alkyl chains; and R and R' represent the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF.sub.3 or --SCH.sub.3 radicals. Said compounds of the formula I are effective and useful as antiglaucomic and antipsychotic agents and also as additive agents in the withdrawal treatment of various addictive conditions. Methods for their preparation are also disclosed.
Inventor(s): Silvestrini; Bruno (Rome, IT), Baiocchi; Leandro (Rome, IT)
Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (Rome, IT)
Application Number:06/025,273
Patent Claims: 1. A compound of the formula: ##STR5## wherein "alk" is selected from the group consisting of linear and branched divalent alkene chains having from 1 to 10 carbon atoms; "alk'" is selected from the group consisting of linear and branched divalent alkene chains having from 1 to 5 carbon atoms; and each R and R' is selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, halogen, alkyloxy having from 1 to 3 carbon atoms, hydroxy, trifluoromethyl and methylthio.

2. A compound according to claim 1, consisting of the pharmaceutically acceptable non-toxic acid addition salt of formula I.

3. The compound according to claim 1, consisting of 3-[3-[4-(2-tolyl)-1-piperazinyl]propyl]-5,6,7,8-tetrahydro-s-triazol[4,3a] pyridine.

4. The compound according to claim 1, consisting of 3-[2-[4-(2-tolyl)-1-piperazinyl]ethyl]-6,7,8,9-tetrahydro-5H-s-triazol[4,3 a]azepine.

5. The compound according to claim 1, consisting of 3-[2-[4-(2-tolyl)-1-piperazinyl]-ethyl]-5,6,7,8-tetrahydro-s-triazol-[4,3- a]pyridine.

6. The compound according to claim 1, consisting of 3-[2-[4-(3-chloro-phenyl)-1-piperazinyl]-ethyl]-5,6,7,8-tetrahydro-s-triaz ol-[4,3-a]pyridine.

7. The compound according to claim 1, consisting of 3-[2-[4-(2-tolyl)-1-piperazinyl]-propyl/-6,7,8,9-tetrahydro-5H-s-triazol-[ 4,3-a]azepine.

8. The compound according to claim 1, consisting of 3-[2-[4-(2,5-di-chlorophenyl)-1-piperazinyl]-ethyl]-6,7,8,9-tetrahydro-5h- s-triazol[4,3-a]azepine.

9. The compound according to claim 1, consisting of 3-[2-[4-(2-methoxyphenyl-1-piperazinyl]-ethyl]-6,7,8,9-tetrahydro-5H-s-tri azol[4,3-a]-azepine.
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