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Serving leading biopharmaceutical companies globally:

Farmers Insurance
US Department of Justice
Boehringer Ingelheim

Generated: November 21, 2017

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Claims for Patent: 4,250,113

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Claims for Patent: 4,250,113

Title: Chemical compounds
Abstract:Compounds of the formula: ##STR1## wherein R represents the group --CH.sub.2 CH.sub.2 OH or --CH.sub.2 CHOHCH.sub.2 OH, particularly in racemic or optically active form, are employed as active ingredients in X-ray contrast agents for intracerebral, but particularly for vascular use. The compounds are prepared by reacting 5-(N-acetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide or an O-acetyl derivative thereof with an appropriate hydroxyalkylating agent and subsequently, if necessary, hydrolysing any unwanted O-acetyl groups.
Inventor(s): Nordal; Vegard (Oslo, NO), Holtermann; Hugo (Oslo, NO)
Assignee: Nyegaard & Co. A/S (Oslo, NO)
Application Number:06/069,589
Patent Claims: 1. Compounds of the general formula: ##STR9## (wherein R represents the group --CH.sub.2 CH.sub.2 OH or --CH.sub.2 CHOHCH.sub.2 OH).

2. 5-(N-2-Hydroxye thylacetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide.

3. 5-(N-2,3-Dihydroxypropyl)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)is ophthalamide.

4. The compound:

(+)-5-(N-2-Hydroxyethylacetamido)-2-4,6-triiodo-N,N'-bis(2,3-dihydroxypropy l)isophthalamide;

(-)-5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropy l)isophthalamide; or

racemic 5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)i sophthalamide.
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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Chinese Patent Office
Johnson and Johnson

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