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Last Updated: April 26, 2024

Claims for Patent: 4,233,285

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Summary for Patent: 4,233,285

Title:	Mercaptocarboxylic acid radiopharmaceuticals
Abstract:	Mercaptocarboxylic acid chelated heavy metal radioisotope pharmaceuticals and methods for making them.
Inventor(s):	Winchell; Harry S. (Lafayette, CA), Lin; Tz-Hong (Berkeley, CA)
Assignee:	Medi-Physics, Inc. (Emeryville, CA)
Application Number:	05/359,719
Patent Claims:	1. A radiopharmaceutical comprising a complex of a mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least one mercapto group with a radioactive heavy metal ion produced by reduction with stannous chloride in the presence of the chelating agent wherein said complex is formed at a pH of from about 2 to 4 and the mole ratio of said metal chelating agent to stannous chloride present to reduce such metal ion is about three to one. 2. The radiopharmaceutical of claim 1 wherein said chelating agent is selected from the group consisting of mercaptoacetic acid, 2-mercaptopropionic acid, 3-mercaptopropionic acid, mercaptosuccinic acid and 2,3-dimercaptosuccinic acid. 3. The radiopharmaceutical of claim 2 wherein said agent is 2,3-dimercaptosuccinic acid and said heavy metal ion is technetium 99m. 4. A reagent for producing a radiopharmaceutical comprising an aqueous solution containing mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least mercapto group, 99-m-technetium pertechnetate and stannous chloride, where the mole ratio of said chelating agent to stannous chloride is about 3 to 1 and the pH of said solution being from about 2 to about 4. 5. The composition of claim 4 wherein said chelating agent is selected from the group consisting of mercaptoacetic acid, 2-mercaptopropionic acid, 3-mercaptopropionic acid, mercaptosuccinic acid and 2,3-dimercaptosuccinic acid. 6. The composition of claim 4 wherein said agent is 2,3-dimercaptosuccinic acid. 7. A method of imaging the renal cortex, brain abnormalities, tumors and myocardial infarcts of a patient comprising intravenously injecting said patient with a radiopharmaceutical comprising a complex of a mercaptocarboxylic acid metal chelating agent with a radioactive heavy metal ion produced by reduction with stannous chloride, wherein said complex is formed at a pH of from 2 to 4 and the mol ratio of said metal chelating agent to stannous chloride present to produce metal ion is about three to one, and scanning with a suitable apparatus. 8. The method of claim 7 wherein said chelating agent is selected from the group consisting of mercaptoacetic acid, 2-mercaptopropionic acid, 3-mercaptopropionic acid, mercaptosuccinic acid and 2,3-dimercaptosuccinic acid. 9. The method of claim 8 wherein said metal ion is technetium-99m and said chelating agent is 2,3-dimercaptosuccinic acid.

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