Last Updated: June 24, 2026

Claims for Patent: 4,216,211

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Summary for Patent: 4,216,211

Title:	Therapeutic composition
Abstract:	Phosphonate compounds are employed in the treatment of hypoxias and ischemic tissue diseases.
Inventor(s):	Marion D. Francis
Assignee:	Procter and Gamble Co
Application Number:	US05/847,190
Patent Claims:	1. A process for increasing the level of 2,3-diphosphoglycerate in the blood of a human or lower animal in need of such treatment, comprising administering to said human or lower animal sufficient organophosphonate compound selected from the group consisting of vicinal organophosphonates of the formula ##STR4## and geminal organophosphonates of the formula ##STR5## and pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to about 10; R, R1 and R2 are H,--CH2 OH, C1 -C20 alkyl or cycloalkyl, C2 -C20 alkenyl, aryl, phenylethyl, benzyl, halogen, amino, substituted amino, --CH2 COOH, --CH2 PO3 H2, --CH(PO3 H2) (OH) or --CH2 CH(PO3 H2)2 ; R3 is H, C1 -C20 alkyl or cycloalkyl, C2 -C20 alkenyl, aryl, phenylethyl, benzyl, halogen, amino, substituted amino, --CH2 COOH, --CH2 PO3 H2, --CH(PO3 H2) (OH) or --CH2 CH(PO3 H2)2 ; and R4 is H, lower alkyl, amino, benzyl, halogen, OH, --CH2 COOH, --CH2 PO3 H2 or --CH2 CH2 PO3 H2 to increase the blood level of said 2,3-diphosphoglycerate. 2. A process according to claim 1 wherein the organophosphonate compound is a member selected from the group consisting of ethane-1-hydroxy-1,1-diphosphonic acid and the pharmaceutically-acceptable salts and esters thereof. 3. A process according to claim 2 wherein the organophosphonate compound is a sodium salt of ethane-1-hydroxy-1,1-diphosphonic acid. 4. A process according to claim 1 wherein the organophosphonate compound is a member selected from the group consisting of methanediphosphonic acid and the pharmaceutically-acceptable salts and esters thereof. 5. A process according to claim 1 wherein the organophosphonate compound is a member selected from the group consisting of methanedichlorodiphosphonic acid and the pharmaceutically-acceptable salts and esters thereof.

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