Claims for Patent: 4,215,215

Summary for Patent: 4,215,215

Title:	9-Phenyl-nonate traene compounds
Abstract:	Novel 9-phenyl 5,6-dimethyl-nona-2,4,6,8-tetraenoic acid, tetraenal or tetraenol derivatives useful as anti-tumor agents.
Inventor(s):	Werner Bollag, Rudolf Ruegg, Gottlieb Ryser
Assignee:	Hoffmann La Roche Inc
Application Number:	US06/055,437
Patent Claims:	1. A compound of the formula: ##STR17## wherein R1 and R2 are lower alkyl; R3 is hydrogen, lower alkyl, lower alkoxy, lower alkenyloxy, nitro, amino, lower alkylamino, lower alkanoylamino or N-heterocyclyl; R4 is lower alkoxy; R5 is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, amino, lower alkanoylamino, lower alkylamino or N-heterocyclyl; and R6 is alkanoyloxymethylene, alkenyloxycarbonyl, alkynyloxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)-carbamoyl, N-heterocyclylcarbonyl, or alkoxycarbonyl where its alkoxy moiety is unsubstituted or substituted with alkylamino, morpholino, piperdyl, pyridyl, alkyl substituted piperidyl or alkyl substituted pyridyl,or pharmaceutically acceptable salts thereof. 2. A compound of the formula: ##STR18## wherein R1 and R2 are lower alkyl; R3 is hydrogen or lower alkyl; R4 is lower alkoxy; R5 is hydrogen, lower alkyl or lower alkoxy; and R6 is alkoxycarbonyl or carbamoyl,or pharmaceutically acceptable salts thereof. 3. The compound of claim 1 wherein R6 is alkoxycarbonyl. 4. The compound of claim 3 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid methyl ester. 5. The compound of claim 3 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl ester. 6. The compound of claim 3 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2-trans,4-cis,6-trans,8-trans-tetraen-1-oic acid ethyl ester. 7. The compound of claim 3 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic isopropyl ester. 8. The compound of claim 3 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid butyl ester. 9. The compound of claim 3 wherein the alkoxy group of the alkoxycarbonyl moiety is substituted with alkylamino, morpholino, piperidyl, pyridyl, alkyl substituted piperidyl or alkyl substituted pyridyl. 10. The compound of claim 9 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid diethyl aminoethyl ester. 11. The compound of claim 9 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid (3-pyridyl)methyl ester. 12. The compound of claim 1 wherein R6 is alkynyloxycarbonyl. 13. The compound of claim 12 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid allyl ester. 14. The compound of claim 1 wherein R6 is alkynyloxycarbonyl. 15. The compound of claim 14 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid propargyl ester. 16. The compound of claim 1 wherein R6 is alkanoyloxymethylene. 17. The compound of claim 16 wherein said compound is 1-acetoxy-9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraene. 18. The compound of claim 1 wherein R6 is carbamoyl. 19. The compound of claim 18 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid amide. 20. The compound of claim 1 wherein R6 is mono or dilower alkylcarbamoyl. 21. The compound of claim 20 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl amide. 22. The compound of claim 21 wherein said compound is 9-(4-methoxy-2,3,5,6-tetramethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl amide. 23. The compound of claim 20 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid diethylamide. 24. The compound of claim 1 wherein R6 is N-heterocyclylcarbonyl. 25. The compound of claim 24 wherein said compound is 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid morpholide. 26. The compound of claim 1 wherein R5 is lower alkenyl. 27. The compound of claim 1 wherein at least one of R3 and R5 is nitro and R6 is alkoxycarbonyl. 28. The compound of claim 27 wherein said compound is 9-(4-methoxy-3-nitro-2,6-dimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl ester. 29. The compound of claim 1 wherein at least one of R3 and R5 is lower alkylamino and R6 is alkoxycarbonyl. 30. The compound of claim 1 wherein at least one R3 or R5 is lower alkenyloxy.