|Abstract:||A tablet suitable for use in the treatment of microbial infections, which tablet comprises from 80 to 98% (w/w) of a combination of a 2,4-diaminopyrimidine with a sulphonamide and not more than 20% (w/w) of both a granulating and a disintegrating agent, the combination having a particle size less than 40 .mu.m and the disintegrating agent having a swelling capacity greater than 5 ml/g.|
|Inventor(s):||Torode; Allan J. (Basildon, GB2), Harden; David (Sidcup, GB2), Spence; John (Bickley, GB2)|
|Assignee:||Burroughs Wellcome Co. (Research Triangle Park, NC)|
1. A tablet which comprises from 90 to 98% (w/w) of a combination of trimethoprim with sulphamethoxazole, the combination having a particle size from 1 to 40 .mu.m, from 1 to
5% (w/w) of a granulating agent, and from 1 to 5% (w/w) of a disintegrating agent having a swelling capacity from 5 to about 25 ml/g, the tablet having a hardness of about 9.8 to 20 kg and a disintegration time of less than 9 minutes.
2. A tablet according to claim 1, wherein the tablet has a hardness of about 9.8 to about 14.8 kg.
3. A tablet according to claim 1 wherein the disintegration time is from 45 seconds to about 5 minutes.