Flexible Flat-Rate Plans

Flat-rate pricing for predictable budgeting

Short-term plans for project- or client-based billing

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,200,647

« Back to Dashboard

Claims for Patent: 4,200,647

Title: Vitamin A compositions to treat rheumatic disease
Abstract:Compositions and methods for treating rheumatic diseases with vitamin A compounds are disclosed.
Inventor(s): Bollag; Werner (Basel, CH), Reber; Kurt (Ettingen, CH)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:05/968,712
Patent Claims: 1. A method for orally treating rheumatic disease in a mammal comprising orally administering to said mammal a retinoid or a pharmaceutically acceptable salt thereof, in an amount effective for treating rheumatic disease.

2. The method of claim 1 wherein the retinoid is vitamin A in its naturally occurring form or a synthetic analog of vitamin A.

3. The method of claim 1 wherein the retinoid is selected from the group consisting of vitamin A acid, 13-cis-vitamin A acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oi c acid ethylamide, 9-(2,6-dichloro-4-methoxy-5-methyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetra en-1-oic acid ethyl ester, 4-O-.alpha.-D-glucopyranosyl-D-glucopyranosyl-9-(4-methoxy-2,3,6-trimethyl -phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenate, 3,7-dimethyl-9-(2,4,5-trimethyl-3-thienyl)-nona-2,4,6,8-tetraen-1-oic acid ethyl ester, 9-(4-methoxy-2,3,6-trimethyl-phenyl)4-fluoro-3,7-dimethyl-nona-2,4,6,8-tet raen-1-oic acid ethyl ester and 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oi c acid ethyl ester, or the pharmaceutically acceptable salts thereof.

4. The method of claim 1 or 2 wherein the rheumatic disease is rheumatoid arthritis.

5. The method of claim 1 or 2 wherein the rheumatic disease is Bechterew's ankylopoietic spondylarthritis.

6. The method of claim 1 or 2 wherein the rheumatic disease is psoriatic arthopathy.

7. The method of claim 3 wherein the composition is orally administered at a daily dose of about 0.25 to about 2.0 mg/kg. of body weight of said mammal.

8. The method of claim 3 or 7 wherein the retinoid is 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oi c acid ethyl ester.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.