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Generated: December 15, 2017

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Claims for Patent: 4,200,647

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Claims for Patent: 4,200,647

Title: Vitamin A compositions to treat rheumatic disease
Abstract:Compositions and methods for treating rheumatic diseases with vitamin A compounds are disclosed.
Inventor(s): Bollag; Werner (Basel, CH), Reber; Kurt (Ettingen, CH)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:05/968,712
Patent Claims: 1. A method for orally treating rheumatic disease in a mammal comprising orally administering to said mammal a retinoid or a pharmaceutically acceptable salt thereof, in an amount effective for treating rheumatic disease.

2. The method of claim 1 wherein the retinoid is vitamin A in its naturally occurring form or a synthetic analog of vitamin A.

3. The method of claim 1 wherein the retinoid is selected from the group consisting of vitamin A acid, 13-cis-vitamin A acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oi c acid ethylamide, 9-(2,6-dichloro-4-methoxy-5-methyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetra en-1-oic acid ethyl ester, 4-O-.alpha.-D-glucopyranosyl-D-glucopyranosyl-9-(4-methoxy-2,3,6-trimethyl -phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenate, 3,7-dimethyl-9-(2,4,5-trimethyl-3-thienyl)-nona-2,4,6,8-tetraen-1-oic acid ethyl ester, 9-(4-methoxy-2,3,6-trimethyl-phenyl)4-fluoro-3,7-dimethyl-nona-2,4,6,8-tet raen-1-oic acid ethyl ester and 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oi c acid ethyl ester, or the pharmaceutically acceptable salts thereof.

4. The method of claim 1 or 2 wherein the rheumatic disease is rheumatoid arthritis.

5. The method of claim 1 or 2 wherein the rheumatic disease is Bechterew's ankylopoietic spondylarthritis.

6. The method of claim 1 or 2 wherein the rheumatic disease is psoriatic arthopathy.

7. The method of claim 3 wherein the composition is orally administered at a daily dose of about 0.25 to about 2.0 mg/kg. of body weight of said mammal.

8. The method of claim 3 or 7 wherein the retinoid is 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oi c acid ethyl ester.
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