|Title:||6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome|
|Abstract:||6-n-Propyl (ethyl or allyl)-8.beta.-methoxy-(methyl-sulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonisn.|
|Inventor(s):||Kornfeld; Edmund C. (Indianapolis, IN), Bach; Nicholas J. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
1. A process for inhibiting the secretion of prolactin in mammals which comprises administering to a mammal in which there is an excess of prolactin being secreted a prolactin-lowering
dose of a compound of the formula ##STR3## wherein Y is O, SO, SO.sub.2 or S, R.sup.1 is ethyl, n-propyl, or allyl, X is H, Cl or Br and R.sup.2, R.sup.3 and R.sup.4 when taken singly are hydrogen, and R.sup.2 and R.sup.3, and R.sup.3 and R.sup.4, when
taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof.
2. A process for treating a patient suffering from Parkinson's syndrome and in need of treatment which comprises administering a dose effective to ameliorate the Parkinsonism symptoms of a compound of the formula ##STR4## wherein Y is O, SO, SO.sub.2 or S, R.sup.1 is ethyl, n-propyl, or allyl, X is H, Cl or Br and R.sup.2, R.sup.3 and R.sup.4 when taken singly are hydrogen, and R.sup.2 and R.sup.3, and R.sup.3 and R.sup.4, when taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof.
3. A method according to claim 2 in which D-6-n-propyl-8.beta.-methylmercaptomethylergoline or a pharmaceutically acceptable salt thereof is administered.
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