Claims for Patent: 4,180,582

Summary for Patent: 4,180,582

Title:	6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
Abstract:	6-n-Propyl (ethyl or allyl)-8β-methoxy-(methyl-sulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonisn.
Inventor(s):	Edmund C. Kornfeld, Nicholas J. Bach
Assignee:	Eli Lilly and Co
Application Number:	US06/002,515
Patent Claims:	1. A process for inhibiting the secretion of prolactin in mammals which comprises administering to a mammal in which there is an excess of prolactin being secreted a prolactin-lowering dose of a compound of the formula ##STR3## wherein Y is O, SO, SO2 or S, R1 is ethyl, n-propyl, or allyl, X is H, Cl or Br and R2, R3 and R4 when taken singly are hydrogen, and R2 and R3, and R3 and R4, when taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof. 2. A process for treating a patient suffering from Parkinson's syndrome and in need of treatment which comprises administering a dose effective to ameliorate the Parkinsonism symptoms of a compound of the formula ##STR4## wherein Y is O, SO, SO2 or S, R1 is ethyl, n-propyl, or allyl, X is H, Cl or Br and R2, R3 and R4 when taken singly are hydrogen, and R2 and R3, and R3 and R4, when taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof. 3. A method according to claim 2 in which D-6-n-propyl-8β-methylmercaptomethylergoline or a pharmaceutically acceptable salt thereof is administered.