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Summary for Patent: 4,177,290
|Abstract:||Novel acetamide derivatives have been discovered to have useful pharmaceutical activity on the central nervous system. They may be prepared by reacting the corresponding ester or acid halide with the appropriately substituted amine.|
|Inventor(s):||Lafon; Louis (Paris, FR)|
|Assignee:||Laboratoire L. Lafon (Maisons Alfort, FR)|
|Patent Litigation and PTAB cases:||See patent lawsuits and PTAB cases for patent 4,177,290|
1. An acetamide derivative selected from the compounds of formula I ##STR8## wherein ring a and ring b are each substituted zero, one or more times by substituents selected from the
group consisting of fluoro, chloro, bromo, trifluoromethyl, nitro, amino, alkyl of 1 to 4 carbon atoms, inclusive, alkoxy of 1 to 4 carbon atoms, inclusive, and methylenedioxy; wherein Z is the radical >CHSO--; and wherein A is selected from the
group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, inclusive, hydroxyalkyl of 1 to 4 carbon atoms, inclusive, and a group of formula R.sub.1 R.sub.2 N--Y--wherein Y is a divalent linear or branched chain hydrocarbon radical having 1 to 4 carbon
atoms, inclusive, in the chain, and R.sub.1 and R.sub.2, being the same or different, are selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, inclusive; and addition salts of the compounds wherein A is a basic group.
2. A compound of claim 1 wherein A is R.sub.1 R.sub.2 N--Y--wherein Y is a divalent linear or branched chain hydrocarbon radical having 1 to 4 carbon atoms, inclusive, in the chain, and R.sub.1 and R.sub.2, together with the N atom to which they are attached, form a group selected from the group consisting of dimethylamine and diethylamine.
3. A compound of claim 1 wherein rings a and b are both unsubstituted and A is hydrogen, and pharmacologically acceptable acid addition salts thereof.
4. A compound of claim 1 which is benzhydrylsulphinylacetamide.
5. A pharamaceutical composition having activity on the central nervous system and consisting of, as an essential active ingredient, an active amount of a compound of claim 1.
6. The compound of claim 1, wherein Z is --CHSO-- and A is hydrogen, alkyl of 1 to 4 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms.
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