Last Updated: June 9, 2026

Claims for Patent: 4,166,182

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,166,182

Title:	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
Abstract:	Novel ergoline compounds of the following formula are described: wherein R<1> is ethyl, n-propyl, or allyl; Y is O, S, SO, or SO2; X is hydrogen, chloro, or bromo; the dotted line represents the optinal presence of a double bond; and the pharmaceutically-acceptable acid addition salts thereof. The compounds are useful to inhibit prolactin secretion or to treat Parkinson's syndrome.
Inventor(s):	Edmund C. Kornfeld, Nicholas J. Bach
Assignee:	Eli Lilly and Co
Application Number:	US05/875,978
Patent Claims:	1. A compound of the formula ##STR3## wherein Y is O, SO, SO2 or S, R1 is n-propyl, X is H, Cl or Br and R2, R3 and R4 when taken singly are hydrogen, and R2 and R3, and R3 and R4, when taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof. 2. A compound according to claim 1 in which Y is S. 3. A compound according to claim 1, said compound being D-6-n-propyl-8β-methylmercaptomethylergoline. 4. A compound according to claim 1, said compound being D-6-n-propyl-8-methylmercaptomethyl-8-ergolene. 5. A compound according to claim 1, said compound being D-6-n-propyl-8β-methylmercaptomethyl-9-ergolene. 6. A compound according to claim 1, said compound being D-6-n-propyl-8β-methylmercaptomethylergoline mesylate. 7. A compound according to claim 1 in which Y is S, X is H and R1 is n-propyl. 8. A compound according to claim 1, said compound being D-6-n-propyl-8β-methoxymethylergoline mesylate.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.