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Claims for Patent: 4,158,055

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Claims for Patent: 4,158,055

Title: Administration of 16.alpha.,17.alpha.-cyclopentylidenedioxy-9.alpha.-fluor O-11.beta.,21-dihydroxy-1,4-pregnadiene-3,20-dione 21-acetate
Abstract:A method of treating topical inflammation in mammals by the administration of 16.alpha.,17.alpha.-cyclopentylidenedioxy-9.alpha.-fluoro-11.beta.,21-dihy droxy-1,4-pregnadiene-3,20-dione 21-acetate in a pharmaceutically acceptable carrier.
Inventor(s): Shultz; Walter (Spring Valley, NY), Sieger; George M. (Montvale, NJ), Krieger; Charles (Clifton, NJ)
Assignee: American Cyanamid Company (Stamford, CT)
Application Number:05/754,917
Patent Claims: 1. A method of ameliorating inflammation in a mammal which comprises administering topically to said mammal an anti-inflammatory effective amount of 16.alpha.,17.alpha.-cyclopentylidenedioxy-9.alpha.-fluoro-11.beta.,21-dihy droxy-1,4-pregnadiene-3,20-dione 21-acetate in association with a topical pharmaceutically acceptable carrier.

2. A method in accordance with claim 1, wherein the anti-inflammatory agent is incorporated in a topical cream.

3. A method in accordance with claim 1, wherein the anti-inflammatory agent is incorporated in a topical ointment.

4. A method in accordance with claim 1, wherein the anti-inflammatory agent is incorporated in a topical foam.

5. A method in accordance with claim 1, wherein the anti-inflammatory agent is incorporated in an ophthalmic ointment.

6. A method in accordance with claim 1, wherein the anti-inflammatory agent is incorporated in a topical lotion.

7. A method of treating inflammation in a mammal comprising administering topically to said mammal an anti-inflammatory effective amount of the steroid, 16.alpha.,17.alpha.-cyclopentylidenedioxy-9.alpha.-fluoro-11.beta.,21-dihy droxy-1,4-pregnadiene-3,20-dione 21-acetate in association with a topical pharmaceutically acceptable carrier in which the steroid is present in a concentration range of from about 0.01% to about 0.50%.
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