You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 18, 2024

Claims for Patent: 4,138,475

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,138,475

Title:	Sustained release pharmaceutical composition
Abstract:	Sustained release pharmaceutical composition consisting of a hard gelatine capsule containing film coated spheroids, the spheroids comprising propranolol, or a pharmaceutically-acceptable salt thereof, in admixture with non-water-swellable microcrystalline cellulose, and the said spheroids having a film coat comprising ethylcellulose optionally together with hydroxypropyl methylcellulose and/or a plasticizer.
Inventor(s):	McAinsh; James (Macclesfield, GB2), Rowe; Raymond C. (Macclesfield, GB2)
Assignee:	Imperial Chemical Industries Limited (London, GB2)
Application Number:	05/833,339
Patent Claims:	1. A sustained release pharmaceutical composition consisting of a hard gelatine capsule containing film coated spheroids, the said spheroids comprising, prior to coating, 40 to 65% by weight of propranolol, or a pharmaceutically-acceptable acid-addition salt thereof, in admixture with non-water-swellable microcrystalline cellulose, and the said spheroids having a film coat comprising ethylcellulose or ethycellulose and hydroxpropyl methylcellulose. 2. The composition claimed in claim 1 in which the uncoated spheroids contain 50 to 60% by weight of propranolol hydrochloride and 50 to 40% by weight of non-water-swellable microcrystalline cellulose, respectively. 3. The composition claimed in claim 1 in which the film coat comprises 5 to 15% by weight of the coated spheroids. 4. The composition claimed in claim 1 in which the ethylcellulose has a viscosity of 50 cps at 20.degree. C. 5. The composition claimed in claim 1 in which the hydroxypropyl methylcellulose has a viscosity of 6 cps at 20.degree. C. 6. The composition claimed in claim 1 in which the film coat comprises 80 to 100% by weight of ethylcellulose and 20 to 0% by weight of hydroxypropyl methylcellulose. 7. The composition claimed in claim 1 in which the film coat contains up to 20% by weight of a plasticizer. 8. The composition claimed in claim 1 which contains 100 to 200 mg. of propranolol or a pharmaceutically-acceptable acid-addition salt thereof. 9. The composition claimed in claim 1 in which, prior to coating, the spheroids contain 60% by weight of propranolol hydrochloride in admixture with 40% by weight of non-water-swellable microcrystalline cellulose, and the spheroids have a film coat consisting of 90% by weight of ethylcellulose having a viscosity of 50 cps at 20.degree. C. and 10% by weight of hydroxypropyl methylcellulose having a viscosity of 6 cps at 20.degree. C., the film coat comprising 9 to 10% by weight of the coated spheroids, and the said composition containing 160 mg. of propranolol hydrochloride.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.