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|Title:||Antimicrobial polycyclic nitrofurans|
|Abstract:||2-Nitrobenzofurans in which the furan ring is either fused to or substituted by a fused bicyclic system, which are active as antimicrobial agents, processes for their use and intermediates therefor are described.|
|Inventor(s):||Scherrer; Robert A. (White Bear Lake, MN), Stern; Richard M. (Cottage Grove, MN)|
|Assignee:||Riker Laboratories, Inc. (Northridge, CA)|
1. A compound of the formula ##STR4## wherein X and X' are individually hydrogen, fluorine, chlorine, bromine or carboxyl,
Y is hydrogen, fluorine, chlorine, bromine, carboxyl, carboxymethyl or, together with Z, can form a propylene chain,
Z and Z' are individually hydrogen or together can complete a benzo ring,
provided that the compound contains one and only one of the rings including Y and Z, and Z and Z', and provided further that the compound contains not more than a single carboxyl function, and, when the compound contains a carboxyl function, pharmaceutically acceptable salts thereof.
2. A compound according to claim 1 of the formula ##STR5## wherein x and x' are individually hydrogen, halogen or carboxyl,
Y is hydrogen, halogen or carboxyl, provided that the compound contains not more than a single carboxyl function and, when the compound contains a carboxyl function, pharmaceutically acceptable salts thereof.
3. A method for arresting or inhibiting the growth of microorganisms comprising contacting microorganisms with a compound according to claim 1 in an amount sufficient to arrest or inhibit the growth of said microorganisms.
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