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Generated: December 17, 2017

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Claims for Patent: 4,112,097

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Claims for Patent: 4,112,097

Title: Antihypertensive agents
Abstract:Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazo line, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.
Inventor(s): Winn; Martin (Deerfield, IL), Kyncl; Jaroslav (Lake Bluff, IL), Dunnigan; Daniel Ambrose (Winthrop Harbor, IL), Jones; Peter Hadley (Lake Forest, IL)
Assignee: Abbott Laboratories (North Chicago, IL)
Application Number:05/760,895
Patent Claims: 1. A pharmaceutical composition useful as an antihypertensive comprising an active amount of a compound selected from the class consisting of 2-[4-(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquin azoline and pharmaceutically acceptable acid addition salts thereof and a pharmaceutically acceptacle carrier.

2. The composition of claim 1 wherein the compound is 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline hydrochloride.

3. The composition of claim 1 wherein the compound is 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine hydrochloride.

4. The composition of claim 2 wherein said carrier comprises an aqueous vehicle.

5. A method of treating hypertension in a mammal comprising administering to a mammal so afflicted, a therapeutically effective amount of a compound selected from the class consisting of 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine and pharmaceutically acceptable acid addition salts thereof.

6. The method of claim 5 wherein said compound is 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxy-quinazoline hydrochloride.

7. The method of claim 5 wherein said compound is 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine hydrochloride.
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