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Last Updated: April 25, 2024

Claims for Patent: 4,112,097

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Summary for Patent: 4,112,097

Title:	Antihypertensive agents
Abstract:	Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazo line, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.
Inventor(s):	Winn; Martin (Deerfield, IL), Kyncl; Jaroslav (Lake Bluff, IL), Dunnigan; Daniel Ambrose (Winthrop Harbor, IL), Jones; Peter Hadley (Lake Forest, IL)
Assignee:	Abbott Laboratories (North Chicago, IL)
Application Number:	05/760,895
Patent Claims:	1. A pharmaceutical composition useful as an antihypertensive comprising an active amount of a compound selected from the class consisting of 2-[4-(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquin azoline and pharmaceutically acceptable acid addition salts thereof and a pharmaceutically acceptacle carrier. 2. The composition of claim 1 wherein the compound is 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline hydrochloride. 3. The composition of claim 1 wherein the compound is 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine hydrochloride. 4. The composition of claim 2 wherein said carrier comprises an aqueous vehicle. 5. A method of treating hypertension in a mammal comprising administering to a mammal so afflicted, a therapeutically effective amount of a compound selected from the class consisting of 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine and pharmaceutically acceptable acid addition salts thereof. 6. The method of claim 5 wherein said compound is 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxy-quinazoline hydrochloride. 7. The method of claim 5 wherein said compound is 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine hydrochloride.

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