Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
UBS
Citi
US Department of Justice
Daiichi Sankyo
Julphar
Chubb
Fuji
Teva

Generated: May 21, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,094,966

« Back to Dashboard

Summary for Patent: 4,094,966
Title: Iodobenzene derivatives and X-ray contrast media containing the same
Abstract:The present invention provides new iodobenzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.
Inventor(s): Tilly; Guy (Aulnay-sous-Bois, FR), Hardouin; Michel Jean Charles (Aulnay-sous-Bois, FR), Lautrou; Jean (Aulnay-sous-Bois, FR)
Assignee: Laboratoires Andre Guerbet (Aulnay-sous-Bois, FR)
Application Number:05/748,323
Patent Claims: 1. An iodobenzene derivative selected from the group consisting of a compound of formula ##STR113## in which: R.sub.1 is selected from the group consisting of hydrogen, a radical having the formula ##STR114## R.sub.5 and R.sub.6 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxy alkyl, and a radical of the formula ##STR115## R.sub.7 being a lower alkanoyl radical and R.sub.8 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxylakyl,

R.sub.2 is selected from the group consisting of hydrogen, a radical having the formula ##STR116## in which R.sub.9 and R.sub.10 have the meanings given for R.sub.5 and R.sub.6, and a radical of the formula ##STR117## in which 11 has the meaning given for R.sub.7 or represents a hydrogen atom and R.sub.12 has the meaning given for R.sub.8,

R.sub.3 is selected from the group consisting of hydrogen, a radical having the formula ##STR118## in which R.sub.13 and R.sub.14 have the meanings given for R.sub.5 and R.sub.6, and a radical of the formula ##STR119## in which R.sub.15 has the meaning given for R.sub.7 or represents hydrogen and R.sub.16 has the meaning given for R.sub.8,

R.sub.4 is selected from the group consisting of hydrogen, lower alkyl and lower hydroxylakyl, a lower alkyl ester thereof and a salt with a pharmaceutically acceptable base.

2. An iodobenzene derivative selected from 2,4,6-tri-iodo-3-N-methylcarbamyl-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethylcarbamyl-phenyl]carbamyl-methyl} aminoacetamidobenzoic acid and a salt thereof with a pharmaceutically acceptable base.

3. An iodobenzene derivative selected from 2,4,6-triiodo-3-N-methylacetamido-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethyl-carbamyl)-phenyl] carbamyl-methyl} aminoacetamidobenzoic acid and a salt thereof with a pharmaceutically acceptable base.

4. An iodobenzene derivative selected from 2,4,6-triiodo-3-N-methylcarbamyl-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethyl-carbamyl)-phenyl]carbamyl-methyl} amino-N-methylacetamido-benzoic acid and a salt thereof with a pharmaceutically acceptable base.

5. An X-ray contrast mdium comprising an aqueous solution of an effective amount of a compound as claimed in claim 1.

6. An X-ray contrast medium comprising an aqueous solution of an effective amount of a pharmacologically acceptable salt of a compound as claimed in claim 1.

7. An X-ray contrast medium as claimed in claim 6 in which 100 ml of said solution contains 5-100 g of said salt.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Covington
Baxter
McKesson
Colorcon
Medtronic
Citi
US Department of Justice
QuintilesIMS
Daiichi Sankyo

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.