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Claims for Patent: 4,087,545

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Claims for Patent: 4,087,545

Title: Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
Abstract:Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiemetic drugs.
Inventor(s): Archer; Robert A. (Indianapolis, IN), Lemberger; Louis (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:05/658,437
Patent Claims: 1. A process for providing prevention and treatment of emesis and nausea in mammals which comprises administering to a nauseated mammal an anti-emetic dose of a compound represented by the formula ##STR9## wherein R' is either C.sub.7 -C.sub.10 normal alkyl or is the group ##STR10## wherein R" is C.sub.2 -C.sub.7 alkyl and R.sup.v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C.sub.1 -C.sub.4 alkanoyl, in an amount effective to prevent nausea.

2. A process according to claim 1 in which a dose of from 0.1 to 100 mgs per day of the drug is administered.

3. A process according to claim 1 in which a dose of from 1 to 20 mgs. per day of the drug is administered.

4. A process according to claim 1 in which the drug is administered by the oral route.

5. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6- dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

6. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6- dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

7. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimet hyl-9H-dibenzo[b,d]pyran-9-one is administered.
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