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|Title:||Oxime ethers having anti-depressive activity|
|Abstract:||Novel 4'-trifluoromethylvalerophenone 0-(2-aminoethyl)oximes are found to exhibit a strong anti-depressive activity based on a strong serotone potentiation but with the absence of monoamino/oxidase inhibition and undesirable side effects.|
|Inventor(s):||Welle; Hendricus Bernardus Antonius (Utrecht, NL), Claassen; Volkert (Weesp, NL)|
|Assignee:||U.S. Philips Corporation (New York, NY)|
1. Oxime ether compounds of the formula ##STR10## and salts thereof with pharmaceutically acceptable acids, in which formula R is a cyano group, a cyanomethyl group, a
methoxymethyl group or an ethoxymethyl group.
2. The 5-Methoxy-4'-trifluoromethylvalerophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 1.
3. The 5-Ethoxy-4'-trifluoromethylvalerophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 1.
4. An oxime compound of the formula: ##STR11## wherein R is cyano or cyanomethyl.
5. The 4-Cyano-4'-trifluoromethylbutyrophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 4.
6. The 5-Cyano-4'-trifluoromethylvalerophenone O-(2-aminoethyl) oxime and salts thereof with pharmaceutically acceptable acids of claim 4.
7. An antidepressive composition comprising a compound of claim 1 in an antidepressively effective amount and a pharmaceutically acceptable carrier therefore.
8. A method of treating patients suffering from depression comprising administering to said patients a composition of claim 7 in an antidepressively effective amount.
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