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Claims for Patent: 4,070,462

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Claims for Patent: 4,070,462

Title: Steroid ointment
Abstract:An improved ointment for the topical administration of steroids is comprised of a therapeutically effective amount of a 17-mono or 17,21-diester of betamethasone in a non-aqueous base comprised of 5-15% of a glycol solvent, 1-3% of a principle emulsifying agent; 0-7% of a secondary emulsifying agent; and 70-90% of a petrolatum base.
Inventor(s): Ecker; Varda (New York, NY)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:05/735,854
Patent Claims: 1. A method of treating inflammation which comprises applying to the skin a topical formulation comprising an amount effective to treat said inflammation of a dermatologically acceptable anti-inflammatory 17-mono or 17,21-diester of betamethasone in a non-aqueous, water-miscible solvent-in-oil base comprising

- 15% of a non-aqueous, water-miscible solvent consisting essentially of a glycol solvent selected from the group consisting of

1,2-propylenediol, butylene glycol, hexylene glycol and mixtures thereof;

1-3% of propylene glycol monostearate;

0-7% of white or yellow wax; and

70-90% of petrolatum.

2. The method of claim 1 wherein the 17-mono or 17,21-diester of betamethasone is betamethasone 17,21-dipropionate.

3. The method of claim 1 wherein the 17-mono or 17,21-diester of betamethasone is betamethasone valerate.

4. The method of claim 1 wherein the 17-mono or 17,21-diester of betamethasone is present in an amount of 0.01-0.2% by weight.

5. The method of claim 1 wherein the glycol solvent is 1,2-propylenediol.

6. The method of claim 1 wherein the wax is white wax.

7. A topical ointment for the treatment of inflammation which comprises an amount effective to treat said inflammation of a dermatologically acceptable anti-inflammatory 17-mono or 17,21-diester of betamethasone in a non-aqueous, water-miscible solvent-in-oil base comprising

5-15% of a non-aqueous, water-miscible solvent consisting essentially of a glycol solvent selected from the group consisting of 1,2-propylenediol, butylene glycol, hexylene glycol and mixtures thereof;

1-3% of propylene glycol monostearate;

0-7% of white or yellow wax; and

70-90% of petrolatum.

8. The ointment of claim 7 wherein the 17-mono or 17,21-diester of betamethasone is betamethasone 17,21-dipropionate.

9. The ointment of claim 7 wherein the 17-mono or 17,21-diester of betamethasone is betamethasone 17-valerate.

10. The ointment of claim 7 wherein the 17-mono or 17,21-diester of betamethasone is present in an amount of 0.01-0.02% by weight.

11. The ointment of claim 7 wherein the glycol solvent is 1,2-propylenediol.

12. The ointment of claim 7 wherein the wax is white wax.

13. A method of treating psoriasis which comprises applying to the skin an ointment of claim 7.

14. A method of treating psoriasis which comprises applying to the skin an ointment of claim 8.

15. A method of treating psoriasis which comprises applying to the skin an ointment of claim 9.

16. A method of treating psoriasis which comprises applying to the skin an ointment of claim 10.

17. A method of treating psoriasis which comprises applying to the skin an ointment of claim 11.

18. A method of treating psoriasis which comprises applying to the skin an ointment of claim 12.
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