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Serving 500+ biopharmaceutical companies globally:

Express Scripts
Colorcon
Covington
Fish and Richardson
Federal Trade Commission
Fuji
US Army
McKinsey
Deloitte
Johnson and Johnson

Generated: August 17, 2017

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Title: X-ray contrast media
Abstract:The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.
Inventor(s): Tilly; Guy (Aulnay-sous-Bois, FR), Hardouin; Michel Jean Charles (Aulnay-sous-Bois, FR), Lautrou; Jean (Aulnay-sous-Bois, FR)
Assignee: Laboratoires Andre Guerbet (Aulnay-sous-Bois, FR)
Application Number:05/747,810
Patent Claims: 1. An iodobenzene derivative selected from the group consisting of a compound of formula ##STR96## in which: R.sub.1 is selected from the group consisting of a radical having the formula ##STR97## R.sub.5 and R.sub.6 being each selected from the group consisting of hydrogen, lower alkyl, lower hydroxyalkyl and lower alkanoyloxyalkyl and a radical of the formula ##STR98## R.sub.7 being lower alkanoyl and R.sub.8 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxyalkyl,

R.sub.2 is selected from the group consisting of a radical having the formula ##STR99## in which R.sub.9 and R.sub.10 have the meanings given for R.sub.5 and R.sub.6, and a radical of the formula ##STR100## in which R.sub.11 has the meaning given for R.sub.7 or represents hydrogen and R.sub.12 has the meaning given for R.sub.8,

at least one of the radicals R.sub.1 and R.sub.2 being of ##STR101## R.sub.4 is selected from the group consisting of hydrogen, lower alkyl and lower hydroxyalkyl,

R.sub.15 is selected from the group consisting of hydrogen, lower alkanoyl and polyhydroxy lower alkanoyl,

R.sub.16 is selected from the group consisting of hydrogen, lower alkyl, lower hydroxyalkyl and lower alkanoyl,

a is 0 or 1

n is an integer from 1 to 5

b is 1 or 2

and the different R.sub.2, R.sub.4 and n which exist when b = 2 may have the same or different meanings,

a lower alkyl ester thereof and a salt with a pharmaceutically acceptable base.

2. An X-ray contrast medium comprising an aqueous solution of an effective amount of a compound as claimed in claim 1.

3. An X-ray contrast medium comprising an aqueous solution of an effective amount of a pharmaceutically acceptable salt of a compound as claimed in claim 1.

4. An X-ray contrast medium as claimed in claim 3 in which 100 ml of said solution contains 5-100 g of said salt.
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Merck
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McKesson
Moodys
Harvard Business School

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