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Claims for Patent: 4,062,966

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Claims for Patent: 4,062,966

Title: 1-Aryl-2-(1-imidazolyl) alkyl ethers and thioethers
Abstract:Novel 1-aryl-2-(1-imidazolyl)alkyl ethers and thioethers having anti-fungal properties are disclosed.
Inventor(s): Gymer; Geoffrey E. (Sandwich, EN)
Assignee: Pfizer Inc. (New York, NY)
Application Number:05/676,104
Patent Claims: 1. A 1-aryl-2-(1-imidazolyl)alkyl ether or thioether having the formula: ##STR12## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkyl of from 1 to 6 carbon atoms; Ar is phenyl, substituted phenyl, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms, thienyl or halothienyl; Z is oxygen or sulfur; n is 1 or 2; and Y is thienyl or substituted thienyl group, said substituents being halogen, alkyl of from 1 to 6 carbon atoms or alkoxy of from 1 to 6 carbon atoms.

2. A compound as claimed in claim 1 in which Ar is phenyl or substituted phenyl.

3. A compound as claimed in claim 1 in which Z is oxygen.

4. A compound as claimed in claim 1 in which Z is sulfur.

5. A compound as claimed in claim 1 in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom.

6. A compound as claimed in claim 2 in which Ar is a 2,4-dichlorophenyl group.

7. A compound as claimed in claim 1 in which n is 1.

8. A compound as claimed in claim 1 in which Y is a thienyl or halothienyl group.

9. 1-[2,4-dichloro-.beta.-(3-thienylmethoxy)phenethyl]imidazole.

10. 1-[2,4-dichloro-.beta.-(5-chloro-2-thienylmethoxy)phenethyl]imidazole.

11. 1-[2,4-dichloro-.beta.-(2-chloro-3-thienylmethoxy)phenethyl]imidazole.

12. 1-[2,4-dichloro-.beta.-(2-thienylmethoxy)phenethyl]imidazole.

13. 1-[2,4-dichloro-.beta.-(2,5-dichloro-3-thienylmethoxy)pheneth yl]imidazole.

14. 1-[2,4-di chloro-.beta.-(5-chloro-2-thienylmethylthio)phenethyl]imidazole.

15. 1-[2,4-dichloro-.beta.-(3-thienylmethylthio)phenethyl]imidazole.

16. 1-[2-(5-chloro-2-thienyl)-2-(3-chloro-2-thienylmethoxy)ethyl] imidazole.

17. A composition in dosage unit form useful for the treatment of fungal infections comprising a pharmaceutical carrier containing from about 10 mg. to about 3,000 mg. of a compound as claimed in claim 1.

18. A method of treating fungal infections in animals which comprises parentally or orally administering to an animal in need of such treatment an antifungal effective amount of a compound as claimed in claim 1.
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