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Claims for Patent: 4,061,779

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Claims for Patent: 4,061,779

Title: Naphthalene derivatives having anti-inflammatory activity
Abstract:4-(6'-Methoxy-2'-naphthyl) butan-2-one is described as having anti-inflammatory activity and an improved therapeutic ratio.
Inventor(s): Lake; Anthony William (Saffron Waldon, EN), Rose; Carl John (London, EN)
Assignee: Beecham Group Limited (UK)
Application Number:05/748,676
Patent Claims: 1. A pharmaceutical composition useful for treating inflammation in humans which comprises an anti-inflammatory effective amount of the compound of the formula: ##STR26## in combination with a pharmaceutically acceptable carrier.

2. A pharmaceutical composition according to claim 1 in oral administration form.

3. A pharmaceutical composition according to claim 1 in unit dose form for oral administration to humans which comprises from 20 mg to 1000 mg of a compound of the formula: ##STR27##

4. A pharmaceutical composition according to claim 3 in tablet or capsule form which comprises from 100 mg to 600 mg of a compound of the formula: ##STR28##

5. A pharmaceutical composition useful for the treatment of rheumatic and arthritic conditions in humans which comprises a therapeutically effective amount of a compound of the formula ##STR29## in combination with a pharmaceutically acceptable carrier.

6. A pharmaceutical composition according to claim 5 in oral administration form.

7. A method of reducing inflammation in humans which comprises administering to a human in need thereof an amount of a composition of claim 1 sufficient to produce an anti-inflammatory effect without an undesired oestrogenic effect.

8. A method according to claim 7 wherein the composition is administered orally.

9. A method according to claim 8 wherein the composition is in the form of a unit dose for oral administration wherein each unit dose contains from 20 mg to 1000 mg of said compound.

10. A method according to claim 8 wherein the composition is in the form of a unit dose for oral administration wherein each unit dose contains from 100 mg to 600 mg of the compound.

11. A method of treating rheumatic and arthritic conditions in humans which comprises administering to a human in need thereof an amount of a composition of claim 5 sufficient to provide relief from the rheumatic or arthritic condition being treated.

12. A method according to claim 11 wherein the composition is administered orally.

13. Solid 4-(6'-methoxy-2'-naphthyl)butan-2-one hving a melting poit of not less than 78.5.degree. C.
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