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|Title:||Rapidly resorbable glibenclamide|
|Abstract:||A blood sugar lowering composition comprising as the active material particulate glibenclamide having a surface area of about 3 to 10 m.sup.2 /g in admixture with a pharmacologically acceptable non-ionic wetting agent present in about 2 to 20 times the weight of the glibenclamide. The preferred wetting agent is polyoxyethylene stearate present in about 5 to 10 times the weight of the glibenclamide.|
|Inventor(s):||Rothe; Werner (Hockenheim, DT), Heinemann; Helmut (Heidelberg, DT), Schmidt; Felix Helmut (Mannheim-Seckenheim, DT), Betzien; Gunter (Mannheim, DT)|
|Assignee:||Boehringer Mannheim G.m.b.H. (Mannheim, DT)|
1. A blood sugar lowering composition comprising microfine particulate glibenclamide having a surface area of about 3 to 10 m.sup.2 /g in admixture with a pharmacologically
acceptable non-ionic wetting agent present in about 2 to 20 times the weight of the glibenclamide.
2. The composition of claim 1, wherein the active material has a particle surface area of 5 to 10 m.sup.2 /g.
3. The composition of claim 1, wherein the dispersion agent is present in about 5 to 10 times the weight of the glibenclamide.
4. The composition of claim 1, wherein the wetting agent is polyoxyethylene stearate.
5. A unit dose of the composition of claim 4, wherein the glibenclamide is present in about 0.5 to 10 mg and the polyoxyethylene stearate is present in about 5 to 10 times the weight of the glibenclamide.
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