Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
Deloitte
Cipla
McKinsey
Baxter
Medtronic
US Army
Colorcon
Queensland Health

Generated: May 21, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,058,552

« Back to Dashboard

Summary for Patent: 4,058,552
Title: Esters of p-carbonylphenoxy-isobutyric acids
Abstract:This invention is concerned with esters of p-carbonylphenoxy-isobutyric acids of the general formulae: ##STR1## WHEREIN R is a phenyl group substituted by one or two halogen atoms; R' is H, CH.sub.3, C.sub.6 H.sub.5, SCH.sub.3, OCH.sub.3, or, SO.sub.2 CH.sub.3 ; R" is CH.sub.3 or C.sub.2 H.sub.5 ; Y is C.sub.1 -C.sub.4 alkoxy, phenoxy, phenoxy substituted by one or two halogen atoms, or, OCH.sub.2 O--CO--C(CH.sub.3).sub.3 ; Z is C.sub.1 -C.sub.4 alkyl, phenyl or R; Nr.sub.1 r.sub.2 is N(CH.sub.3).sub.2 N(C.sub.2 H.sub.5).sub.2, morpholino, piperidino, azepino, pyrrolidino. This invention is also concerned with acid addition salts obtained from formula Ia compounds with acids. Compounds of formulae I and Ia are useful as hypocholesterolemiant and hypolipidemiant agents.
Inventor(s): Mieville; Andre (Lausanne, CH)
Assignee: Orchimed SA (CH)
Application Number:05/600,127
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 4,058,552
Patent Claims: 1. A novel ester of p-carbonylphenoxy-isobutyric acid having the formula ##STR18## wherein R is a phenyl group substituted by one or two halogen atoms;

R' is H, CH.sub.3, C.sub.6 H.sub.5, SCH.sub.3, OCH.sub.3, or, SO.sub.2 CH.sub.3 ;

R" is CH.sub.3 or C.sub.2 H.sub.5 ; and

Y is C.sub.1- C.sub.4 alkoxy, phenoxy, phenoxy substituted by one or two halogen atoms, or, OCH.sub.2 O-CO-C (CH.sub.3).sub.3.

2. A novel ester according to claim 1 having the formula ##STR19## wherein R is 4-ClC.sub.6 H.sub.4, 3-ClC.sub.6 H.sub.4, 3,4-(Cl).sub.2 - C.sub.6 H.sub.3 and 2,6-(Cl).sub.2 - C.sub.6 H.sub.3, and, Y is OCH.sub.3, OC.sub.2 H.sub.5, OCH(CH.sub.3).sub.2.

3. An ester of p-carbonylphenoxy-isobutyric acid according to claim 1 wherein R is 4-chlorophenyl.

4. An ester of p-carbonylphenoxy-isobutyric acid according to claim 1 wherein R is 3,4-dichlorophenyl.

5. Isopropyl p-(4-chlorobenzoyl)phenoxy-isobutyrate.

6. A therapeutic composition useful for treating patients in order to reduce their blood cholesterol and lipids content, which comprises, in association with a pharmaceutically acceptable excipient, a therapeutically effective amount of at least a compound according to claim 1.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Teva
Cerilliant
Argus Health
Cipla
Accenture
Healthtrust
Mallinckrodt
Medtronic

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.