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Claims for Patent: 4,053,628

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Claims for Patent: 4,053,628

Title: Composition
Abstract:There is described a composition comprising a substantially clear, sterile aqueous solution containing as active ingredient a therapeutically useful proportion of 1,3-bis(2-carboxy-chromon-5-yloxy)-propan-2-ol, or a pharmaceutically acceptable (e.g. the di-sodium) salt thereof, or of 5,5'-[[5,5'-(2-hydroxytrimethylene)dioxy]bis[4-oxo-4H-1-benzopyran-2-yl]]t etrazole, or a pharmaceutically acceptable (e.g. the di-sodium) salt thereof. The composition is indicated for the treatment of conditions of the eye and the nose.
Inventor(s): Stevenson; Neil Arthur (Loughborough, EN), Wardell; George (Loughborough, EN)
Assignee: Fisons Limited (London, EN)
Application Number:05/677,274
Patent Claims: 1. A method of treatment of conditions of the eye or nose, in which conditions allergy or immune reactions play a contributory part, which method comprises administration of 1,3-bis(2-carboxychromon-5 -yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, topically or by sub-conjunctival injection to a patient having such a condition.

2. A method for the treatment of conditions of the eye or nose in which conditions allergy or immune reactions play a contributory part which comprises administering topically or by sub-conjunctival injection to a patient suffering from such condition a composition which comprises a sterile aqueous solution containing 1,3-bis(2-carboxy-chromon-5-yloxy)-propan-2-ol or a pharmaceutically acceptable salt thereof as an active ingredient, wherein, in said composition, the said active ingredient is present in an amount of from 0.1 to 10% w/v, the said composition containes less than about 0.40 ppm of ions of metals in Groups IIa, Ib, IIb and IVb of the Periodic Table and of the transition metals, the said composition being a substantially clear, sterile aqueous solution.

3. A method for the treatment of conditions of the eye or nose in which conditions allergy or immune reactions play a contributory part which comprises administering topically or by sub-conjunctival injection to a patient suffering from such condition a composition which comprises a sterile aqueous solution containing 1,3-bis(2-carboxy-chromon-5-yloxy)-propan-2-ol or a pharmaceutically acceptable salt thereof as an active ingredient, wherein, in said composition, the said active ingredient is present in an amount of from 0.1 to 10% w/v, the composition contains less than about 20ppm of ions of metals in Groups IIa, Ib, IIb and IVb of the Periodic Table and of the transition metals, the composition contains from about 0.05 to 0.1% w/v of a pharmaceutically acceptable chelating or sequestering agent, and the said composition is a substantially clear aqueous solution.

4. A method according to claim 1 wherein the condition to be treated is a condition of the eye selected from the group of vernal catarrh, marginal corneal ulceration or infiltration, occular effects of hay fever, non-specific conjunctivitis, Herpes Simplex Keratitis and Conjunctivitis, Herpes Zoster Keratitis and Conjunctivitis, adenovirus infections, phlyctenular conjunctivitis, corneal homograft rejection, Trachoma, anterior uveitis and drug sensitivity.

5. A method according to claim 1 wherein the condition to be treated is a condition of the nose selected from the group of seasonal rhinitis, perennial rhinitis, nasal polyps and allergic manifestations of the nasopharynx.

6. A method according to claim 4 wherein the dosage to be administered is from 0.66 to 1.32 mg. of the 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol or pharmaceutically acceptable salt thereof to the affected eye from 2 to 4 times per day.
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