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Generated: December 17, 2017

DrugPatentWatch Database Preview

Claims for Patent: 4,051,141

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Claims for Patent: 4,051,141

Title: Thieno[3,2-c]pyridine derivatives
Abstract:Thieno[3,2-c]pyridine derivatives having the formula: ##STR1## in which X is S; R is a phenyl or benzoyl radical optionally substituted with 1-3 halogen atoms or lower alkyl, lower alkoxy, hydroxy or nitro; R.sub.1 is hydrogen, halogen, hydroxy or lower alkyl; R.sub.2 is hydrogen or halogen and n is 1 or 2, and in which the symbols R.sub.1 may be different in each CHR.sub.1 when n is 2; and their pharmaceutically acceptable acid addition salts. Said derivatives are therapeutically useful for their anti-inflammatory, vasodilatator and blood plate aggregation inhibitor action.
Inventor(s): Castaigne; Albert Rene Joseph (Toulouse, FR)
Assignee: Centre d'Etudes pour l'Industrie pharmaceutique (Toulouse, FR)
Application Number:05/660,248
Patent Claims: 1. A compound selected from the derivatives of the formula: ##STR6## in which X is sulfur; R is selected from the group consisting of phenyl, phenyl substituted with 1 or 2 halogen atoms or alkyl having 1-6 carbon atoms or alkoxy having 1-6 carbon atoms or hydroxy or nitro, benzoyl, and benzoyl substituted with chloro or fluoro or alkyl having 1-6 carbon atoms or alkoxy having 1-6 carbon atoms or 1 or 2 hydroxy groups or nitro; R.sub.1 is selected from the group consisting of hydrogen, halogen, hydroxy and alkyl having 1-6 carbon atoms; R.sub.2 is selected from hydrogen and halogen and n is 1 or 2, and in which the symbols R.sub.1 may have different meanings in each radical --(CHR.sub.1)-- when n is 2; and the pharmaceutically acceptable acid addition salts thereof.

2. A compound selected from 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.

3. A compound selected from 5-(4-methoxybenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.

4. A compound selected from 5-(3,4,5-trimethoxybenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.

5. A compound selected from 5-parachlorobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.

6. A compound selected from 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine and its pharmaceutically acceptable acid addition salts.
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Queensland Health
Deloitte
Federal Trade Commission
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Medtronic
AstraZeneca
Chubb
Cipla
Accenture
Dow

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