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Generated: August 21, 2017

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Title: Pharmaceutical compositions containing a 1-(2,6-dimethyl-phenoxy)-2-amino-alkane and method of use
Abstract:Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, and R.sub.1 is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as anticonvulsives and antiarrhythmics.
Inventor(s): Koppe; Herbert (Ingelheim am Rhein, DT), Zeile; Karl (Ingelheim am Rhein, DT), Kummer; Werner (Ingelheim am Rhein, DT), Stahle; Helmut (Ingelheim am Rhein, DT), Danneberg; Peter (Ingelheim am Rhein, DT)
Assignee: Boehringer Ingelheim GmbH (Ingelheim am Rhein, DT)
Application Number:05/653,296
Patent Claims: 1. A pharmacodynamic dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective anticonvulsive or antiarrhythmic amount of a racemic or optically active compound of the formula ##STR11## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms and R.sub.1 is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof.

2. A composition of claim 1, where said compound is racemic or optically active 1-(2',6'-dimethyl-phenoxy)-2-amino-propane or a non-toxic, pharmacologically acceptable acid addition salt thereof.

3. A composition of claim 1, where said compound is racemic or optically active 1-(2',6'-dimethyl-phenoxy)-2-amino-pentane or a non-toxic, pharmacologically acceptable acid addition salt thereof.

4. A composition of claim 1, where said compound is racemic or optically active 1-(2',6'-dimethyl-phenoxy)-2-amino-hexane or a non-toxic, pharmacologically acceptable acid addition salt thereof.

5. The method of suppressing convulsions and alleviating cardiac arrhythmia in a warm-blooded animal in need of such treatment, which comprises administering to said animal an effective anticonvulsive or antiarrhythmic dose of a racemic or optically active compound of the formula ##STR12## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms and R.sub.1 is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof.

6. The method of claim 5, where said compound is racemic or optionally active 1-(2',6'-dimethyl-phenoxy)-2-amino-propane or a non-toxic, pharmacologically acceptable acid addition salt thereof.

7. The method of claim 5, where said compound is racemic or optically active 1-(2',6'-dimethyl-phenoxy)-2-amino-pentane or a non-toxic, pharmacologically acceptable acid addition salt thereof.

8. The method of claim 5, where said compound is racemic or optically active 1-(2',6'-dimethyl-phenoxy)-2-amino-hexane or a non-toxic, pharmacologically acceptable acid addition salt thereof.
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