Claims for Patent: 4,027,019

Summary for Patent: 4,027,019

Title:	3-Oximes of D-17.alpha.-ethynyl-19-nortestosterone esters and method
Abstract:	3-Oximes of D-17.alpha.-ethynyl-19-nortestosterone esters and derivatives thereof have pre- and post-coital activity for the suppression of fertility.
Inventor(s):	Shroff; Arvin Pranlal (Piscataway, NJ)
Assignee:	Ortho Pharmaceutical Corporation (Raritan, NJ)
Application Number:	05/652,000
Patent Claims:	1. A compound in the D series of the formula: ##STR5## wherein R is alkanoyl of from 2 to 10 carbon atoms and R' is a member selected from the group consisting of methyl and ethyl. 2. The compound of claim 1 wherein R' is ethyl. 3. The compound of claim 2 wherein R is caproyl. 4. The compound of claim 2 wherein R is acetyl. 5. The compound of claim 2 wherein R is propionyl. 6. The compound of claim 2 wherein R is decanoyl. 7. The compound of claim 1 wherein R' is methyl. 8. The compound of claim 7 wherein R is acetyl. 9. A method of preparing a compound in the D series of claim 1 of the formula: ##STR6## which comprises reacting a ketone in the D series of formula: ##STR7## with an hydroxylamine hydrohalide in the presence of a base, wherein R is alkanoyl of from 2 to 10 carbon atoms and R' is a member selected from the group consisting of methyl and ethyl. 10. The method as in claim 9, wherein the base is a member selected from the group consisting of pyridine, sodium hydroxide, and sodium acetate. 11. The method of claim 9 wherein the hydroxylamine hydrohalide is hydroxylamine hydrochloride. 12. The method as in claim 9, wherein R is acetyl and R' is ethyl. 13. A method of suppressing fertility comprising administering to a female animal an effective antifertility amount of a compound in the D series of claim 1 of formula: ##STR8## wherein R is alkanoyl of from 2 to 10 carbon atoms and R' is a member selected from the group consisting of methyl and ethyl, whereby fertility is suppressed. 14. The method of claim 13 wherein R is acetyl and R' is ethyl. 15. A composition useful in suppressing fertility comprising a compound in the D series of claim 1 of formula: ##STR9## and an estrogenic hormone, wherein R is alkanoyl of from 2-10 carbon atoms and R' is a member selected from the group consisting of methyl and ethyl. 16. The composition of claim 15 wherein R is acetyl, R' is ethyl and the estrogenic hormone is selected from the group consisting of ethinylestradiol, 17.beta.-estradiol, mestranol and 17.alpha.-ethinylestradiol 3-cyclopentyl ether. 17. The composition of claim 16 wherein the estrogenic hormone is ethinylestradiol. 18. A method of suppressing fertility comprising administering to a female an effective antifertility amount of a composition of claim 15. 19. The method of claim 18 wherein R is acetyl, R' is ethyl and the estrogenic hormone is ethinylestradiol.