|Abstract:||Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazo line, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.|
|Inventor(s):||Winn; Martin (Deerfield, IL), Kyncl; Jaroslav (Lake Bluff, IL), Dunnigan; Daniel Ambrose (Winthrop Harbor, IL), Jones; Peter Hadley (Lake Forest, IL)|
|Assignee:||Abbott Laboratories (North Chicago, IL)|
1. A compound selected from the group consisting of 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and
2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine and pharmaceutically acceptable acid addition salts thereof.
2. A compound in accordance with Claim 1: 2-[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline hydrochloride.
3. A compound in accordance with Claim 1: 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine hydrochloride.
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