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Generated: July 28, 2017

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Title: Parenteral benzodiazepine compositions
Abstract:Stable, non-aqueous parenteral dosage forms of benzodiazepine compounds comprise from about 10% to about 65% polyethylene glycol, from about 35% to about 90% propylene glycol, from 0% to about 10% benzyl alcohol, and 1 mg. to 15 mg. of benzodiazepine compound per ml.
Inventor(s): Gomez; Eloy A. (West Chester, PA), Levin; Howard J. (Norristown, PA)
Assignee: American Home Products Corporation (New York, NY)
Application Number:05/351,114
Patent Claims: 1. A parenterally acceptable composition comprising from about 10% to about 65% polyethylene glycol, from about 35% to about 90% propylene glycol, from 0% to about 10% benzyl alcohol, and, per ml. of the above solution, from about 1 mg. to about 15 mg. of a benzodiazepine compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are independently hydrogen or methyl, and R.sup.3 is hydrogen or chlorine, said composition being substantially free of water.

2. A composition according to claim 1 wherein R.sup.1 and R.sup.2 are hydrogen, and R.sup.3 is chlorine.

3. A composition according to claim 1 wherein R.sup.1 is methyl, R.sup.2 is methyl, and R.sup.3 is chlorine.

4. A composition according to claim 2 wherein the polyethylene glycol concentration is about 18%, the propylene glycol concentration is about 80%, and the benzyl alcohol concentration is about 2%.

5. A composition according to claim 2 wherein the polyethylene glycol concentration is about 20%, and the propylene glycol concentration is about 80%.

6. A composition according to claim 3 wherein the polyethylene glycol concentration is about 50% and the propylene glycol concentration is about 50%.
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Serving 500+ biopharmaceutical companies globally:

Dow
Argus Health
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Boehringer Ingelheim
QuintilesIMS
AstraZeneca
Covington

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