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Claims for Patent: 4,012,444

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Claims for Patent: 4,012,444

Title: 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide and physiologically acceptable acid addition salts thereof
Abstract:Compounds of the formula: ##STR1## and physiologically acceptable acid addition salts thereof, in which R.sup.1 is A. an arylalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms and the aryl portion of which may be substituted by one or more alkoxy groups or hydroxy groups; or B. an aryloxyalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms, and the aryloxy portion of which is substituted with one or more alkoxy or hydroxy groups. These compounds have a blocking action on both .alpha.- and .beta.-adrenergic receptors. Processes for the production of these compounds and pharmaceutical compositions containing them are also provided.
Inventor(s): Lunts; Lawrence Henry Charles (London, EN), Collin; David Trevor (London, EN)
Assignee: Allen & Hanburys Limited (London, EN)
Application Number:05/420,547
Patent Claims: 1. 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide or a physiologically acceptable acid addition salt thereof.

2. The compound of claim 1 which is 5-[1-hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide.

3. The compound of claim 1 which is 5-[1-hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide hydrochloride.
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