|Title:|| [Des-gly].sup.10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity|
|Abstract:||An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating lutenizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5-100 .mu.g./kg.|
|Inventor(s):|| Gendrich; Ronald Lee (Waukegan, IL), Rippel; Riemond Henry (Gurnee, IL), Seely; John Hunter (Lake Bluff, IL) |
|Assignee:|| Abbott Laboratories (North Chicago, IL) |
1. A nonapeptide of the formula:
wherein all aminoacids are present in their optical L-configuration and wherein X represents leucyl in the D-configuration.