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Claims for Patent: 4,001,301

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Claims for Patent: 4,001,301

Title: 6-Substituted 2-naphthyl acetic acid derivatives
Abstract:2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, antipyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
Inventor(s): Fried; John H. (Palo Alto, CA), Harrison; Ian T. (Palo Alto, CA)
Assignee: Syntex Corporation (Panama City, PM)
Application Number:05/558,874
Patent Claims: 1. The compounds of the formula: ##STR9## wherein: R.sup.7 is alkoxy having 1 to 6 carbon atoms

one of R.sup.10 and R.sup.11 is hydrogen, the other being methyl or ethyl;

the alkyl esters of the compounds of Formula XIV derived from alkonols having 1 to 12 carbon atoms; and

the pharmaceutically acceptable addition salts thereof.

2. The compounds of claim 1 wherein one of R.sup.10 and R.sup.11 is hydrogen and the other is methyl.

3. The compounds of claim 1 wherein R.sup.7 is methoxy.

4. The compound of formula XIV according to claim 1 wherein R.sup.7 is methoxy; one of R.sup.10 and R.sup.11 is hydrogen and the other is methyl.

5. The compounds of the formula: ##STR10## wherein: R.sup.7 is alkylthio having 1 to 6 carbon atoms;

one of R.sup.10 and R.sup.11 is hydrogen, the other being methyl or ethyl;

the alkyl esters of the compounds of Formula XIV derived from alkanols having 1 to 12 carbon atoms; and

the pharmaceutically acceptable addition salts thereof.

6. The compounds of claim 5 wherein R.sup.7 is methylthio.

7. The compounds of claim 5 wherein one of R.sup.10 and R.sup.11 is hydrogen and the other is methyl.

8. The compound of formula XIV according to claim 5 wherein R.sup.7 is methylthio; one of R.sup.10 and R.sup.11 is hydrogen and the other is methyl.

9. Methyl 6-methoxy-2-naphthyl-.alpha.-methylacetate.

10. 6-Methylthio-2-naphthyl-.alpha.-methylacetic acid.
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