Claims for Patent: 4,923,892

Summary for Patent: 4,923,892

Title:	Tricyclic aromatic compounds
Abstract:	The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R1 is --CH2 --CH2 --, CH2 --O-- or --O--CH2 --; R2 and R3 are the same or different and are each hydrogen, C1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R4 is a single bond or a C1-7 bivalent aliphatic hydrocarbon group and may be joined to the aromatic ring system at the 2,3,8 or 9 positions; n is 0 to 3, and their use as antihistamine and antiasthma agents.
Inventor(s):	O. William Lever, Jr., Harry J. Leighton
Assignee:	SmithKline Beecham Corp
Application Number:	US07/356,884
Patent Claims:	1. A method of treating allergy in a mammal which comprises administering to a mammal in need thereof an effective allergy treatment amount of a compound of formula (I) ##STR10## or a pharmacologically and pharmaceutically acceptable salt thereof; wherein R1 is --CH2 --O--, R2 and R3 are the same or different and are each hydrogen or C1-4 alkyl, R4 is a C1-2 bivalent hydrocarbon group and is joined to the aromatic ring system at the 2 position and n is 2. 2. The method of claim 1 in which R2 and R3 are methyl. 3. A method of claim 1 in which the compound of formula (I) is:(Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acrylic acid. 4. A method of treating asthma in a mammal which comprises administering to a mammal in need thereof an effective asthma treatment amount of a compound of formula (I) ##STR11## or a pharmacologically and pharmaceutically acceptable salt thereof; wherein R1 is --CH2 --O--, R2 and R3 are the same or different and are each hydrogen or C1-4 alkyl, R4 is a C1-2 bivalent hydrocarbon group and is joined to the aromatic ring system at the 2 position and n is 2. 5. The method of claim 4 in which R2 and R3 are methyl. 6. The method of claim 4 in which the compound of formula (I) is:(Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acrylic acid. 7. A pharmaceutical formulation for use in treating allergy or asthma comprising an effective allergy or asthma treatment amount of: ##STR12## or a pharmacologically and pharmaceutically acceptable salt thereof; wherein R1 is --CH2 --O--, R2 and R3 are the same or different and are each hydrogen or C1-4 alkyl, R4 is a C1-2 bivalent hydrocarbon group and is joined to the aromatic ring system at the 2 position and n is 2 and a pharmaceutically acceptable carrier therefore. 8. The formulation of claim 7 in which R1 and R2 are methyl. 9. The formulation of claim 8 in which the compound is:(Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acrylic acid. 10. The formulation of claim 7 in the form of a tablet or capsule. 11. The formulation of claim 8 in the form of a tablet or capsule. 12. The formulation of claim 9 in the form of a tablet or capsule.