Claims for Patent: 3,985,758

Summary for Patent: 3,985,758

Title:	1,4-Dihydropyridine derivatives
Abstract:	There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3- beta -(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are characterized by cerebral vascular dilator activity.
Inventor(s):	Masuo Murakami, Kozo Takahashi, Masaru Iwanami, Masaharu Fujimoto, Tadao Shibanuma, Ryutaro Kawai, Toichi Takenaka
Assignee:	Yamanouchi Pharmaceutical Co Ltd , Bristol Myers Squibb Pharma Co
Application Number:	US05/584,268
Patent Claims:	1. A compound of the formula ##SPC10##wherein R represents hydrogen or lower alkyl; R1 and R2 each represents methyl; R3 represents phenyl, benzyl, halobenzyl, lower alkoxy-benzyl; R4 represents hydrogen, methyl or ethyl; A represents lower alkylene; R5 represents methyl, or lower alkoxy, or lower alkoxy substituted with lower alkoxy, or ##EQU1## in which R3 and R4 have the same meaning as above; and R6 represents nitro or trifluoromethyl. 2. The 1,4-dihydropyridine compound as claimed in claim 1 wherein said R is hydrogen, said R1 and R2 each represents methyl; said R3 represents benzyl; said R4 represents methyl or ethyl; said R5 represents lower alkoxy; and said R6 represents nitro. 3. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino ethyl ester 5-methyl ester. 4. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino) ethyl ester 5-ethyl ester. 5. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino) ethyl ester 5-isopropyl ester. 6. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-ethylamino) ethyl ester 5-isopropyl ester. 7. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino) propyl ester 5-isopropyl ester. 8. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-p-methoxybenzyl-N-methylamino) ethyl ester 5-ethyl ester. 9. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-p-chlorobenzyl-N-methylamino) ethyl ester 5-ethyl ester.