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Claims for Patent: 3,985,758

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Claims for Patent: 3,985,758

Title: 1,4-Dihydropyridine derivatives
Abstract:There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are characterized by cerebral vascular dilator activity.
Inventor(s): Murakami; Masuo (Tokyo, JA), Takahashi; Kozo (Tokyo, JA), Iwanami; Masaru (Yokohama, JA), Fujimoto; Masaharu (Tokyo, JA), Shibanuma; Tadao (Asaka, JA), Kawai; Ryutaro (Shiraoka, JA), Takenaka; Toichi (Tokyo, JA)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JA)
Application Number:05/584,268
Patent Claims: 1. A compound of the formula ##SPC10##

wherein R represents hydrogen or lower alkyl; R.sup.1 and R.sup.2 each represents methyl; R.sup.3 represents phenyl, benzyl, halobenzyl, lower alkoxy-benzyl; R.sup.4 represents hydrogen, methyl or ethyl; A represents lower alkylene; R.sup.5 represents methyl, or lower alkoxy, or lower alkoxy substituted with lower alkoxy, or ##EQU1## in which R.sup.3 and R.sup.4 have the same meaning as above; and R.sup.6 represents nitro or trifluoromethyl.

2. The 1,4-dihydropyridine compound as claimed in claim 1 wherein said R is hydrogen, said R.sup.1 and R.sup.2 each represents methyl; said R.sup.3 represents benzyl; said R.sup.4 represents methyl or ethyl; said R.sup.5 represents lower alkoxy; and said R.sup.6 represents nitro.

3. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino ethyl ester 5-methyl ester.

4. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino) ethyl ester 5-ethyl ester.

5. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino) ethyl ester 5-isopropyl ester.

6. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-ethylamino) ethyl ester 5-isopropyl ester.

7. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino) propyl ester 5-isopropyl ester.

8. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-p-methoxybenzyl-N-methylamino) ethyl ester 5-ethyl ester.

9. The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-p-chlorobenzyl-N-methylamino) ethyl ester 5-ethyl ester.
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