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Claims for Patent: 3,982,021

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Claims for Patent: 3,982,021

Title: Compositions for the treatment of coronary diseases containing tetrahydronaphthyloxy-aminopropanols
Abstract:This invention relates to pharmaceutical compositions for the treatment of coronary diseases comprising a compound having the formula ##SPC1## Wherein R.sup.1 is lower alkyl, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and are hydrogen or lower alkyl, and R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and a pharmaceutically acceptable carrier therefor.
Inventor(s): Hauck; Frederic P. (Somerville, NJ), Cimarusti; Christopher M. (Hamilton, NJ), Narayanan; Venkatachala L. (Hightstown, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:05/621,176
Patent Claims: 1. A pharmaceutical composition useful for the treatment of coronary diseases in mammalian species in need thereof, comprising an effective amount of a compound having the structure ##SPC33##

or a stereoisomer or salt thereof, wherein R.sup.1 is lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and are hydrogen or lower alkyl; and R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and a pharmaceutically acceptable carrier therefor.

2. A pharmaceutical composition in accordance with claim 1 comprising an effective amount of a compound having the formula ##SPC34##

or a stereoisomer or salt thereof, and a pharmaceutically acceptable carrier therefor.

3. A pharmaceutical composition in accordance with claim 2 comprising an effective amount of a compound having the formula ##SPC35##

or a stereoisomer or salt thereof, and a pharmaceutically acceptable carrier therefor.

4. A pharmaceutical composition in accordance with claim 3 comprising an effective amount of 2,3-cis-1,2,3,4-tetrahydro-5-[2-hyroxy-3-(tert-butylamino)propoxy]-2,3-nap hthalenediol and a pharmaceutically acceptable carrier therefor.
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