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Last Updated: March 29, 2024

Claims for Patent: 3,980,790


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Summary for Patent: 3,980,790
Title: 8-Chloro-1-methyl-6-(O-chlo rophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine compositions and method of treatment
Abstract:Therapeutic compositions for treating humans and animals comprising, in dosage unit form, a 8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepi ne compound of the formula ##SPC1## Including the N-oxides and pharmacologically acceptable acid addition salts thereof in combination with a pharmaceutical carrier. The compositions are useful as soporifics and provide a process for inducing sleep.
Inventor(s): Hester, Jr.; Jackson B. (Galesburg, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:05/278,141
Patent Claims: 1. A pharmaceutical composition for inducing sleep comprising, in unit dosage form, from about 0.1 mg. to about 10.0 mg. of 8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazep ine or a pharmacologically acceptable acid addition salt thereof in combination with a pharmaceutical carrier.

2. The composition of claim 1 wherein the 8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepi ne is in the form of the hydrobromic acid addition salt.

3. The composition of claim 1 wherein the 8-chloro-1-methyl-6-(o-chlorophenyl(-4H-s-triazolo[4,3-a][1,4]benzodiazepi ne is in the form of the free base.

4. A process for inducing sleep comprising the administration to a human or animal subject, in unit dosage form, from about 0.001 mg. to about 0.2 mg./kg. body weight of 8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepi ne or a pharmacologically acceptable acid addition salt thereof in association with a pharmaceutical carrier.

5. The composition of claim 4 wherein the 8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepi ne is in the form of the hydrobromic acid addition salt.

6. The composition of claim 4 wherein the 8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepi ne is in the form of the free base.

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