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Claims for Patent: 3,980,789

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Claims for Patent: 3,980,789

Title: 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine compositions and method of treatment
Abstract:Therapeutic compositions for treating humans and animals comprising, in dosage unit form, a 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine compound of the formula ##SPC1## Including the N-oxides and pharmacologically acceptable acid addition salts thereof in combination with a pharmaceutical carrier. The compositions are useful as soporifics and provide a process for inducing sleep.
Inventor(s): Hester, Jr.; Jackson B. (Galesburg, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:05/266,521
Patent Claims: 1. A pharmaceutical composition for inducing sleep comprising, in unit dosage form, from about 0.5 mg. to about 10.0 mg. of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine or a pharmacologically acceptable acid addition salt thereof in combination with a pharmaceutical carrier.

2. The composition of claim 1 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the hydrobromic acid addition salt.

3. The composition of claim 1 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the free base.

4. A process for inducing sleep comprising the administration to a human or animal subject, in unit dosage form from about 0.005 mg. to about 0.2 mg./kg. body weight of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine or a pharmacologically acceptable acid addition salt thereof in association with a pharmaceutical carrier.

5. The composition of claim 4 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the hydrobromic acid addition salt.

6. The composition of claim 4 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the free base.
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