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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Colorcon
Federal Trade Commission
Baxter
Fuji
US Department of Justice
Cerilliant
Cipla
Dow
Covington

Generated: February 20, 2018

DrugPatentWatch Database Preview

Claims for Patent: 3,966,962

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Summary for Patent: 3,966,962
Title: Triacetin solutions of PGE-type compounds
Abstract:A stable dosage form of PGE-type compounds is obtained by dissolving these compounds in triacetin.
Inventor(s): Yalkowsky; Samuel H. (Portage, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:05/562,535
Patent Claims: 1. A stable dosage form of a prostaglandin-like compound of the PGE-type comprising a solution of said compound in triacetin.

2. A stable dosage form according to claim 1 wherein said solution contains said compound in a concentration range 0.1 to 10 mg. per ml. of triacetin.

3. A stable dosage form according to claim 1 wherein said solution is contained in a capsule of a pharmaceutically acceptable water-dispersable material.

4. A stable dosage form according to claim 3 wherein said material contains gelatin and the capsule is soft and elastic.

5. A stable dosage form according to claim 1 wherein said compound is PGE.sub.2, PGE.sub.2 methyl ester, 16,16-dimethyl-PGE.sub.2, 16,16-dimethyl-PGE.sub.2 methyl ester, 15-methyl-PGE.sub.2, 15-methyl-PGE.sub.2 methyl ester, 15(R)-15-methyl-PGE.sub.2, or 15(R)-15-methyl-PGE.sub.2 methyl ester.

6. A stable dosage form according to claim 5 wherein the triacetin solution is contained in a soft elastic gelatin capsule, and said compound is present in a concentration range 0.1 to 10 mg. per ml. of triacetin.

7. A stable dosage form according to claim 4 wherein the compound is 16,16-dimethyl-PGE.sub.2 or 16,16-dimethyl-PGE.sub.2 methyl ester, and said compound is present in a concentration range 0.5 to 5 mg. per ml. of triacetin.

8. A stable dosage form according to claim 4 wherein the compound is 15-methyl-PGE.sub.2 or 15-methyl-PGE.sub.2 methyl ester, and said compound is present in a concentration range 0.5 to 5 mg. per ml. of triacetin.

9. A stable dosage form according to claim 4 wherein the compound is 15(R)-15-methyl-PGE.sub.2 or 15(R)-15-methyl-PGE.sub.2 methyl ester, and said compound is present in a concentration range 0.5 to 5 mg. per ml. of triacetin.

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