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|Title:||16-Oxygenated prostanoic acid derivatives|
|Abstract:||16-Oxygenated prostanoic acid derivatives, displaying valuable pharmacological properties, e.g. gastric anti-secretory, are produced by reaction of an (optionally 3-oxygenated)-5-oxocyclopent-1-enealkanoic/alkenoic acid or ester with the appropriate organometallic reagent.|
|Inventor(s):||Collins; Paul W. (Deerfield, IL), Pappo; Raphael (Skokie, IL)|
|Assignee:||G. D. Searle & Co. (Chicago, IL)|
1. The compound which is racemic methyl 7-[3(R)-hydroxy-2.beta.-(4(RS)-4-hydroxy-4-methyl-trans-1-octenyl)-5-oxocy clopentane]-1.alpha.-heptanoate.
2. The compound which is racemic methyl 7-[3(S)-hydroxy-2.beta.-(4(RS)-4-hydroxy-4-methyl-1-octynyl)-5-oxocyclopen tane]-1.alpha.-heptanoate.
3. The compound which is racemic methyl 7-[3(R)-hydroxy-2.beta.-(4(RS)-4-cyclohexylmethyl-4-hydroxy-4-methyl-trans -1-butenyl)-5-oxocyclopentane]-1.alpha.-heptanoate.