|Title:|| Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor|
|Abstract:||A process for preparing the LH- and FSH-releasing hormone of the formula I which is isolated as the hydrochloride salt and optionally converted to other pharmaceutically acceptable salts or to pharmaceutically acceptable metal complexes.|
|Inventor(s):|| Immer; Hans U. (Mount Royal, CA), Nelson; Verner R. (Kirkland, CA), Gotz; Manfred K. (Hudson, CA) |
|Assignee:|| American Home Products Corporation (New York, NY) |
1. A diagnostic method for distinguishing between hypothalmic and pituitary malfunctions or lesions in humans which comprises administering systemically to a human suspected of such
malfunction from about 1 to 100 micrograms per kilogram of body weight of 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L- arginyl-L-prolylglycinamide or a pharmaceutically acceptable salt thereof, and detecting the rise in the
level of serum leutenizing hormone.
2. The diagnostic method of claim 1 wherein 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L- arginyl-L-prolylglycinamide dihydrochloride is employed and the human is female.