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Claims for Patent: 3,944,671

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Claims for Patent: 3,944,671

Title: Treatment of adrenal malfunction
Abstract:Dextrorotatory .alpha.-(4-aminophenyl)-.alpha.-lower alkylglutarimides or salts thereof normalize the secretion of malfunctioning adrenal glands.
Inventor(s): Dziemian; Robert (Cedar Knolls, NJ), Finch; Neville (West Orange, NJ)
Assignee: Ciba-Geigy Corporation (Ardsley, NY)
Application Number:05/396,969
Patent Claims: 1. A pharmaceutical composition for reducing adrenal hyperfunction, comprising an adrenal secretion reducing amount of the dextrorotatory antipode of an .alpha.-(4-aminophenyl)-.alpha.-lower alkylglutarimide or a therapeutically acceptable acid addition salt thereof, and a pharmaceutical excipient.

2. A composition as claimed in claim 1, wherein the antipode is d-aminoglutethimide or a therapeutically acceptable acid addition salt thereof.

3. A composition as claimed in claim 2, wherein the antipode is the d-aminoglutethimide d-tartrate.

4. A composition as claimed in claim 2, wherein the antipode is the d-aminoglutethimide monophosphate.

5. A composition as claimed in claim 1, wherein the antipode content is about 10 to 90% by weight.

6. A composition as claimed in claim 5, wherein the antipode content is about 20 to 80% by weight.

7. A composition as claimed in claim 1, containing between about 450 and about 1,000 mg of the antipode per oral unit dosage form.

8. A method of treating a mammal suffering from malfunctioning adrenal glands, which consists in administering to him enterally or parenterally an adrenal secretion reducing amount of the composition claimed in claim 1.

9. A method as claimed in claim 8, wherein the effective amount of the antipode is between about 8 and 80 mg per kilogram body weight per day of treatment.

10. A method as claimed in claim 8, wherein the effective amount of the antipode is between about 10 and 30 mg per kilogram body weight per day of treatment.
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