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Serving leading biopharmaceutical companies globally:

Queensland Health
Mallinckrodt
Cerilliant
Baxter
Farmers Insurance
Citi
McKinsey
Express Scripts
UBS
US Army

Generated: January 17, 2018

DrugPatentWatch Database Preview

Claims for Patent: 3,935,267

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Summary for Patent: 3,935,267
Title: Tetrahydronaphthyloxy-aminopropanols and salts thereof
Abstract:This invention relates to new tetrahydronaphthyloxy-aminopropanols and related compounds of the formula ##SPC1## And to salts of such compounds, which are useful in coronary diseases.
Inventor(s): Hauck; Frederic Peter (Somerville, NJ), Cimarusti; Christopher M. (Somerset, NJ), Narayanan; Venkatachala Lakshmi (Hightstown, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:05/203,865
Patent Claims: 1. Compounds of the structure ##SPC39##

and stereoisomers and salts thereof, wherein R.sup.1 is lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and are selected from the group consisting of hydrogen and lower alkyl; and R.sup.8, R.sup.9 and R.sup.10 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy and cycloalkyl.

2. Compounds of the structure ##SPC40##

and stereoisomers and salts thereof, wherein R.sup.1 is lower alkyl, and wherein the two adjacent hydroxy groups are in the cis configuration.

3. The compound in accordance with claim 2 having the name 2,3-cis-1,2,3,4-tetrahydro-5-[2-hydroxy-3-(isopropylamino)propoxy]-2,3-nap hthalenediol.

4. Compounds of the structure ##SPC41##

stereoisomers thereof and salts thereof.

5. The compound in accordance with claim 4 having the name 2,3-cis-1,2,3,4-tetrahydro-5-[2-hydroxy-3-(tert-butylamino)propoxy]-2,3-na phthalenediol.

6. Compounds of the structure ##SPC42##

and stereoisomers and salts thereof, wherein R.sup.1 is lower alkyl.

7. Compounds of the structure ##SPC43##

and stereoisomers and salts thereof, wherein R.sup.1 is lower alkyl.

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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
Healthtrust
UBS
Merck
Johnson and Johnson
Baxter
US Department of Justice
Express Scripts
Mallinckrodt

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